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    BthD BthD selenoprotein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32317, updated on 17-Dec-2024

    Summary

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    Official Symbol
    BthDprovided by FlyBase
    Official Full Name
    BthD selenoproteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030501
    Locus tag
    Dmel_CG11177
    See related
    AllianceGenome:FB:FBgn0030501
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11177; Dmel\CG11177; dselH; dSelH; dselM; SelH
    Summary
    Involved in determination of adult lifespan; embryo development; and salivary gland development. Located in Golgi apparatus. Is expressed in oocyte; organism; ovariole; and salivary gland body primordium. Orthologous to human SELENOH (selenoprotein H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See BthD in Genome Data Viewer
    Location:
    12A8-12A8; 1-44 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13612131..13613228)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13506164..13507261)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ndc80 Neighboring gene toothrin Neighboring gene Transport and Golgi organization 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila selenoprotein BthD is required for survival and has a role in salivary gland development. Kwon SY, et al. Mol Cell Biol, 2003 Dec. PMID 14612395, Free PMC Article
    2. Antioxidant function of a novel selenoprotein in Drosophila melanogaster. Morozova N, et al. Genes Cells, 2003 Dec. PMID 14750951
    3. A short motif in Drosophila SECIS Binding Protein 2 provides differential binding affinity to SECIS RNA hairpins. Takeuchi A, et al. Nucleic Acids Res, 2009 Apr. PMID 19223320, Free PMC Article
    4. Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase B1, reveal a role of selenoproteins in stress resistance. Shchedrina VA, et al. J Biol Chem, 2011 Aug 26. PMID 21622567, Free PMC Article
    5. In silico identification of novel selenoproteins in the Drosophila melanogaster genome. Castellano S, et al. EMBO Rep, 2001 Aug. PMID 11493597, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The selenoprotein, dselH, has an antioxidant function.
      Title: Antioxidant function of a novel selenoprotein in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cell redox homeostasis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in determination of adult lifespan IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in larval salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to redox state NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in salivary gland boundary specification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    BthD selenoprotein
    Names
    BthD-PA
    BthDselenoprotein
    CG11177-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13612131..13613228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132675.3 → NP_572903.3  BthD selenoprotein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572903.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MRZ5, Q962X5, Q9VYB0
      Related
      FBpp0073637
      Conserved Domains (1) summary
      pfam15331
      Location:125 → 216
      TP53IP5; Cellular tumour antigen p53-inducible 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYB0.5 Q9VYB0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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