FMRFaR FMRFamide Receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: FMRFaRprovided by FlyBase
Official Full Name: FMRFamide Receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0035385
Locus tag: Dmel_CG2114
See related: AllianceGenome:FB:FBgn0035385
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2114; Dm FMRFa-R; Dmel\CG2114; DmFR; DrmFMRFa-R; Fmrf R; FMRFa-R; FR
Summary: Enables neuropeptide receptor activity. Involved in several processes, including adult locomotory behavior; behavioral defense response; and neuropeptide signaling pathway. Acts upstream of with a positive effect on positive regulation of dopaminergic synaptic transmission. Located in plasma membrane. Is expressed in embryonic segment and ventral midline of embryo. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (3001716..3011860)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (3001716..3011860)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed
enables peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect positive regulation of synaptic transmission, dopaminergic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

Names: CG2114-PA; CG2114-PB; CG2114-PC; FMRFa receptor; FMRFa-receptor; FMRFaR-PA; FMRFaR-PB; FMRFaR-PC; dFMRFa receptor; fmrf receptor; larval-opioid-receptor

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The following sections contain reference sequences that belong to a specific genome build. Explain