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    CG32751 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318189, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG32751provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052751
    Locus tag
    Dmel_CG32751
    See related
    AllianceGenome:FB:FBgn0052751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3648; Dmel\CG32751
    Summary
    Predicted to enable pantetheine hydrolase activity. Human ortholog(s) of this gene implicated in biotinidase deficiency. Orthologous to several human genes including BTD (biotinidase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG32751 in Genome Data Viewer
    Location:
    5D8-5D8; 1-15 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6196580..6198654, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6090613..6092687, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ca[2+]-channel protein alpha[[1]] subunit T Neighboring gene uncharacterized protein Neighboring gene vanin-like Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental ethanol exposure leads to dysregulation of lipid metabolism and oxidative stress in Drosophila. Logan-Garbisch T, et al. G3 (Bethesda), 2014 Nov 11. PMID 25387828, Free PMC Article
    2. Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster. Blount JR, et al. Biol Open, 2019 May 30. PMID 31097444, Free PMC Article
    3. Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging. Huang J, et al. PNAS Nexus, 2023 Dec. PMID 38059264, Free PMC Article
    4. dGLYAT modulates Gadd45-mediated JNK activation and cell invasion. Xu M, et al. Cell Div, 2022 Aug 6. PMID 35933447, Free PMC Article
    5. Microbiota-induced changes in drosophila melanogaster host gene expression and gut morphology. Broderick NA, et al. mBio, 2014 May 27. PMID 24865556, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pantetheine hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG32751-PA
    CG32751-PB
    pantetheine hydrolase
    NP_001284927.1
    NP_727068.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6196580..6198654 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297998.1 → NP_001284927.1  uncharacterized protein Dmel_CG32751, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284927.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D5SHR9, Q8IRR1, X2JDW2
      UniProtKB/TrEMBL
      C0PPJ7
      Conserved Domains (2) summary
      cd07567
      Location:33 → 329
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
      pfam19018
      Location:324 → 503
      Vanin_C; Vanin C-terminal domain

    2. NM_167061.3 → NP_727068.1  uncharacterized protein Dmel_CG32751, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727068.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PPJ7
      Related
      FBpp0070845
      Conserved Domains (1) summary
      cd07567
      Location:33 → 321
      biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IRR1.2 Q8IRR1

    Gene LinkOut

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