Rab6 Rab6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab6provided by FlyBase
Official Full Name: Rab6provided by FlyBase
Primary source: FLYBASE:FBgn0015797
Locus tag: Dmel_CG6601
See related: AllianceGenome:FB:FBgn0015797
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 136/6; AAF53168; CG6601; Dm Rab6; Dmel\CG6601; DmRab6; drab6; dRab6; Drab6; DRab6; l(2)08323; O18334; rab6; wrt
Summary: Enables GTPase activity. Involved in several processes, including neuron development; oogenesis; and protein targeting to Golgi apparatus. Located in Golgi apparatus; cytoplasmic vesicle; and vacuole. Is expressed in several structures, including adult ensheathing glial cell; brain; imaginal disc; mushroom body; and synaptic neuropil domain. Used to study retinal degeneration. Orthologous to several human genes including RAB6A (RAB6A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 33C4-33C4; 2-46 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (12107221..12109116, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (12107221..12109116, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Rab6 to Rab11 transition is required for dense-core granule and exosome biogenesis in Drosophila secondary cells.
Title: A Rab6 to Rab11 transition is required for dense-core granule and exosome biogenesis in Drosophila secondary cells.
Rab6 promotes localization of the insulin receptor to the plasma membrane.
Title: Rab6 promotes insulin receptor and cathepsin trafficking to regulate autophagy induction and activity in Drosophila.
Rab6 regulates apical cargo trafficking from the trans-Golgi network to recycling endosomes in fly photoreceptors.
Title: Rab6 functions in polarized transport in Drosophila photoreceptors.
Rab6 is required for multiple apical transport pathways but not the basolateral transport pathway in Drosophila photoreceptors.Rab6 is essential for the trans-Golgi network-recycling endosome transport.
Title: Rab6 Is Required for Multiple Apical Transport Pathways but Not the Basolateral Transport Pathway in Drosophila Photoreceptors.
Novel molecular events in the regulation of phagocytosis of infecting viruses by Rab6.
Title: Involvement of Rab6 in the regulation of phagocytosis against virus infection in invertebrates.
Rab6 localizes to Golgi and Golgi-derived membranes and interacts with BicD in establishing cell polarity during oogenesis.
Title: Rab6 and the secretory pathway affect oocyte polarity in Drosophila.
Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis.
Title: Rab6 mediates membrane organization and determinant localization during Drosophila oogenesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0355 (e-PCR)
- UniSTS:37368

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in R7 cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived egg chamber formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intra-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in oocyte microtubule cytoskeleton polarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in autophagosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	HDA more info	PubMed
located_in synapse	HDA more info	PubMed

General protein information

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Preferred Names: Rab6

Names: CG6601-PA; CG6601-PB; Rab protein 6; Rab-protein 6; Rab6-PA; Rab6-PB; warthog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

12107221..12109116 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298940.1 → NP_001285869.1 Rab6, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285869.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18334

UniProtKB/TrEMBL

X2J5T3

Conserved Domains (1) summary

cd01861
Location:13 → 173

Rab6; Rab GTPase family 6 (Rab6)
NM_057824.5 → NP_477172.1 Rab6, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477172.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18334

UniProtKB/TrEMBL

X2J5T3

Related

FBpp0079943

Conserved Domains (1) summary

cd01861
Location:13 → 173

Rab6; Rab GTPase family 6 (Rab6)