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    ppk5 pickpocket 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ppk5provided by FlyBase
    Official Full Name
    pickpocket 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0053289
    Locus tag
    Dmel_CG33289
    See related
    AllianceGenome:FB:FBgn0053289
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33289; Dmel\CG33289
    Summary
    Predicted to enable ligand-gated sodium channel activity. Predicted to be involved in sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including ASIC1 (acid sensing ion channel subunit 1); ASIC2 (acid sensing ion channel subunit 2); and ASIC3 (acid sensing ion channel subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ppk5 in Genome Data Viewer
    Location:
    78D5-78D5; 3-47 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21534660..21536861)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21527760..21529961)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43877 Neighboring gene ACAT-related protein required for viability 1 Neighboring gene Makorin 1 Neighboring gene Regulatory particle non-ATPase 10 Neighboring gene Cytochrome c oxidase subunit 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of PPK26 in Drosophila larval mechanical nociception. Guo Y, et al. Cell Rep, 2014 Nov 20. PMID 25457610
    2. Makorin 1 Regulates Developmental Timing in Drosophila. Tran HT, et al. Mol Cells, 2018 Dec 31. PMID 30396233, Free PMC Article
    3. Two Drosophila DEG/ENaC channel subunits have distinct functions in gustatory neurons that activate male courtship. Liu T, et al. J Neurosci, 2012 Aug 22. PMID 22915128, Free PMC Article
    4. Sensory functions for degenerin/epithelial sodium channels (DEG/ENaC). Ben-Shahar Y. Adv Genet, 2011. PMID 22099690, Free PMC Article
    5. Evolution of the Insect PPK Gene Family. Latorre-Estivalis JM, et al. Genome Biol Evol, 2021 Sep 1. PMID 34390578, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pickpocket 5
    Names
    CG33289-PB
    CG33289-PC
    ppk5-PB
    ppk5-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21534660..21536861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206416.2 → NP_996138.2  pickpocket 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996138.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTW2
      Conserved Domains (1) summary
      pfam00858
      Location:4 → 460
      ASC; Amiloride-sensitive sodium channel

    2. NM_001259940.1 → NP_001246869.1  pickpocket 5, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDF3
      Conserved Domains (1) summary
      pfam00858
      Location:4 → 327
      ASC; Amiloride-sensitive sodium channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDF3 M9NDF3
    Q7KTW2 Q7KTW2

    Gene LinkOut

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