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    CG30016 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246393, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG30016provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050016
    Locus tag
    Dmel_CG30016
    See related
    AllianceGenome:FB:FBgn0050016
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-AE003828.1; Dmel\CG30016
    Summary
    Predicted to enable hydroxyisourate hydrolase activity. Predicted to be involved in purine nucleobase metabolic process. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyloidosis; carpal tunnel syndrome 1; dystransthyretinemic hyperthyroxinemia; and transthyretin amyloidosis. Orthologous to human TTR (transthyretin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG30016 in Genome Data Viewer
    Location:
    47C5-47C5; 2-63 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10874892..10875392, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6762397..6762897, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45136 Neighboring gene long non-coding RNA:CR44302 Neighboring gene no child left behind Neighboring gene TBP-associated factor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. no child left behind encodes a novel chromatin factor required for germline stem cell maintenance in males but not females. Casper AL, et al. Development, 2011 Aug. PMID 21752937, Free PMC Article
    2. A Drosophila overexpression screen for modifiers of Rho signalling in cytokinesis. Gregory SL, et al. Fly (Austin), 2007 Jan-Feb. PMID 18690061
    3. Gene expression in a Drosophila model of mitochondrial disease. Fernández-Ayala DJ, et al. PLoS One, 2010 Jan 6. PMID 20066047, Free PMC Article
    4. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article
    5. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydroxyisourate hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in purine nucleobase metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in purine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG30016-PA
    NP_724982.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10874892..10875392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165804.2 → NP_724982.1  uncharacterized protein Dmel_CG30016 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724982.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8C9
      Related
      FBpp0087336
      Conserved Domains (1) summary
      pfam00576
      Location:7 → 112
      Transthyretin; HIUase/Transthyretin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8C9 A1Z8C9

    Gene LinkOut

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