Mvl Malvolio [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mvlprovided by FlyBase
Official Full Name: Malvolioprovided by FlyBase
Primary source: FLYBASE:FBgn0011672
Locus tag: Dmel_CG3671
See related: AllianceGenome:FB:FBgn0011672
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3671; Dmel\CG3671; DMT1; dNRAMP; mvl; NRM2
Summary: Enables symporter activity and transition metal ion transmembrane transporter activity. Involved in several processes, including positive regulation of iron ion transmembrane transport; sensory perception of sweet taste; and transition metal ion transport. Located in endosome and plasma membrane. Is expressed in several structures, including Malpighian tubule; embryonic/larval hemocyte; gland; gut section; and organism subdivision. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to several human genes including SLC11A2 (solute carrier family 11 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 93B7-93B8; 3-70 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21051383..21060800, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16877105..16886522, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mvl transporter affects food choice behavior via the regulation of dopaminergic innervation of the mushroom bodies.
Title: Drosophila divalent metal ion transporter Malvolio is required in dopaminergic neurons for feeding decisions.
Flies mutant for dNRAMP were protected from virus infection. dNRAMP2 facilitates infection and binding of Sindbis virus in mammalian cells.
Title: Natural resistance-associated macrophage protein is a cellular receptor for sindbis virus in both insect and mammalian hosts.
MCO3 mutants had a mild accumulation of copper, which was suppressed in Mvl mutants, revealing a reciprocal genetic interaction between the two genes.
Title: Iron depletion in the intestines of Malvolio mutant flies does not occur in the absence of a multicopper oxidase.
Mvl is a functional Cu transporter necessary for optimal viability at the cellular and organismal levels.
Title: Malvolio is a copper transporter in Drosophila melanogaster.
The expression of Mvl in the gut and Malpighian tubules within D. melanogaster is reported; the conservation of function between Nramp2 and Mvl in flies and mammals is also discussed.
Title: Immunolocalisation of the D. melanogaster Nramp homologue Malvolio to gut and Malpighian tubules provides evidence that Malvolio and Nramp2 are orthologous.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cadmium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables iron ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables manganese ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables manganese ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables symporter activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in copper ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in copper ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in manganese ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in metal ion transport	IEA Inferred from Electronic Annotation more info
involved_in metal ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of iron ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of sweet taste	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transition metal ion transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: malvolio

Names: /Divalent metal transporter; CG3671-PB; CG3671-PD; CG3671-PE; CG3671-PF; CG3671-PG; CG3671-PH; Mvl-PB; Mvl-PD; Mvl-PE; Mvl-PF; Mvl-PG; Mvl-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

21051383..21060800 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169944.3 → NP_732584.1 malvolio, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732584.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P49283, Q95TT7, Q9VDF5

UniProtKB/TrEMBL

A4V370, Q5U196

Related

FBpp0088507

Conserved Domains (1) summary

TIGR01197
Location:75 → 479

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
NM_001275866.1 → NP_001262795.1 malvolio, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262795.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGL5, Q5U196

Conserved Domains (2) summary

TIGR01197
Location:75 → 479

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

pfam01566
Location:97 → 486

Nramp; Natural resistance-associated macrophage protein
NM_001170197.1 → NP_001163668.1 malvolio, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163668.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P49283, Q95TT7, Q9VDF5

UniProtKB/TrEMBL

A4V370, Q5U196

Conserved Domains (1) summary

TIGR01197
Location:75 → 479

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
NM_079701.5 → NP_524425.2 malvolio, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524425.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P49283, Q95TT7, Q9VDF5

UniProtKB/TrEMBL

A4V370, Q5U196

Related

FBpp0290693

Conserved Domains (1) summary

TIGR01197
Location:75 → 479

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
NM_001260292.1 → NP_001247221.1 malvolio, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247221.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7L4, D3DMH9

Conserved Domains (2) summary

TIGR01197
Location:75 → 479

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters

pfam01566
Location:97 → 486

Nramp; Natural resistance-associated macrophage protein
NM_206529.2 → NP_996251.2 malvolio, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996251.2

Status: REVIEWED

UniProtKB/TrEMBL

D3DML2

Conserved Domains (1) summary

TIGR01197
Location:75 → 479

nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters