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    MYB88 myb domain protein 88 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814812, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MYB88
    Official Full Name
    myb domain protein 88
    Primary source
    TAIR:AT2G02820
    Locus tag
    AT2G02820
    See related
    Araport:AT2G02820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtMYB88; myb domain protein 88; T20F6.4; T20F6_4
    Summary
    Encodes a putative transcription factor (MYB88), involved in stomata development, double loss of MYB88 and FLP (MYB124) activity results in a failure of guard mother cells (GMCs) to adopt the guard cell fate, thus they continue to divide resulting in abnormal stomata consisting of clusters of numerous guard cell-like cells. This phenotype is enhanced in double mutants over the single mutant flp phenotype.
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    Genomic context

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    See MYB88 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    11
    Sequence:
    Chromosome: 2; NC_003071.7 (803656..807895, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene protein kinase 2B Neighboring gene UDP-galactose transporter 1 Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The FOUR LIPS (FLP) and MYB88 genes conditionally suppress the production of nonstomatal epidermal cells in Arabidopsis cotyledons. Yang M. Am J Bot, 2016 Sep. PMID 27620181
    2. The FOUR LIPS and MYB88 transcription factor genes are widely expressed in Arabidopsis thaliana during development. Lei Q, et al. Am J Bot, 2015 Sep. PMID 26391711
    3. The R2R3 MYB transcription factors FOUR LIPS and MYB88 regulate female reproductive development. Makkena S, et al. J Exp Bot, 2012 Sep. PMID 22915737, Free PMC Article
    4. Role of the stomatal development regulators FLP/MYB88 in abiotic stress responses. Xie Z, et al. Plant J, 2010 Dec. PMID 21105921
    5. The Arabidopsis R2R3 MYB proteins FOUR LIPS and MYB88 restrict divisions late in the stomatal cell lineage. Lai LB, et al. Plant Cell, 2005 Oct. PMID 16155180, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FLP and MYB88 inhibit the production of nonstomatal epidermal cells largely in a growth-condition-dependent manner.
      Title: The FOUR LIPS (FLP) and MYB88 genes conditionally suppress the production of nonstomatal epidermal cells in Arabidopsis cotyledons.
    2. Both flp and myb88 genes were expressed in many, previously unreported locations, consistent with the possibility of additional functions for FLP and MYB88. Moreover, expression domains especially of FLP display sharp cutoffs or boundaries.
      Title: The FOUR LIPS and MYB88 transcription factor genes are widely expressed in Arabidopsis thaliana during development.
    3. FLP and MYB88 expression specifically determines the temporal-spatial patterns of PIN3 and PIN7 transcription that are closely associated with their preferential functions during root responses to gravity.
      Title: Transcriptional regulation of PIN genes by FOUR LIPS and MYB88 during Arabidopsis root gravitropism.
    4. FLP and MYB88 restrict the G1/S transition during stomatal formation.
      Title: FOUR LIPS and MYB88 conditionally restrict the G1/S transition during stomatal formation.
    5. FLP and MYB88 are important regulators of entry into megasporogenesis, and probably act via the regulation of cell cycle genes.
      Title: The R2R3 MYB transcription factors FOUR LIPS and MYB88 regulate female reproductive development.
    6. flp-1 myb88 double mutant plants show enhanced sensitivity to drought and salt stress.
      Title: Role of the stomatal development regulators FLP/MYB88 in abiotic stress responses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001035880.3
    NM_001335147.1
    NM_126337.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within guard cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in guard cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in guard mother cell cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in guard mother cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lateral root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in megasporogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organismal-level water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of lateral root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle G1/S phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stomatal complex patterning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of stomatal complex patterning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to gravity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stomatal complex formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    myb domain protein 88
    NP_001030957.1
    • myb domain protein 88 (MYB88); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Homeodomain-like (InterPro:IPR009057), Myb, DNA-binding (InterPro:IPR014778), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Homeodomain-related (InterPro:IPR012287), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: Duplicated homeodomain-like superfamily protein (TAIR:AT1G14350.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_565291.2
    • myb domain protein 88 (MYB88); CONTAINS InterPro DOMAIN/s: SANT, DNA-binding (InterPro:IPR001005), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930), Myb transcription factor (InterPro:IPR015495); BEST Arabidopsis thaliana protein match is: Duplicated homeodomain-like superfamily protein (TAIR:AT1G14350.2); Has 8359 Blast hits to 7654 proteins in 549 species: Archae - 0; Bacteria - 2; Metazoa - 785; Fungi - 539; Plants - 5060; Viruses - 3; Other Eukaryotes - 1970 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      803656..807895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001035880.3 → NP_001030957.1  myb domain protein 88 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030957.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4IRB4, F4IRB5, O64502, Q94GA5
      UniProtKB/TrEMBL
      A0A654ERG0
      Conserved Domains (1) summary
      COG5147
      Location:24 → 141
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]

    2. NM_126337.4 → NP_565291.2  myb domain protein 88 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565291.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654ERG0
      Conserved Domains (3) summary
      smart00717
      Location:32 → 78
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:82 → 126
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:33 → 93
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    3. NM_001335147.1 → NP_001325364.1  myb domain protein 88 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B2X7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4IRB4.1

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