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    CYP710A2 cytochrome P450, family 710, subfamily A, polypeptide 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818012, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP710A2
    Official Full Name
    cytochrome P450, family 710, subfamily A, polypeptide 2
    Primary source
    TAIR:AT2G34490
    Locus tag
    AT2G34490
    See related
    Araport:AT2G34490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cytochrome P450; F13P17.22; family 710; polypeptide 2; subfamily A
    Summary
    Encodes a protein with C22-sterol desaturase activity. The enzyme was shown to catalyze the conversion of both 24-<i>epi</i>-campesterol and &beta;-sitosterol to brassicasterol and stigmasterol, respectively, in the presence of NADPH.
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    Genomic context

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    See CYP710A2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (14535506..14537556, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene urease accessory protein G Neighboring gene Ribosomal protein L18ae/LX family protein Neighboring gene cytochrome P450, family 710, subfamily A, polypeptide 1 Neighboring gene choice-of-anchor C domain protein, putative (Protein of unknown function, DUF642)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato. Morikawa T, et al. Plant Cell, 2006 Apr. PMID 16531502, Free PMC Article
    2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    NM_129001.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables C-22 sterol desaturase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 710, subfamily A, polypeptide 2
    NP_180996.1
    • cytochrome P450, family 710, subfamily A, polypeptide 2 (CYP710A2); FUNCTIONS IN: C-22 sterol desaturase activity, oxygen binding; INVOLVED IN: oxidation reduction; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, conserved site (InterPro:IPR017972), Cytochrome P450, E-class, group I (InterPro:IPR002401); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 710, subfamily A, polypeptide 1 (TAIR:AT2G34500.1); Has 26372 Blast hits to 26256 proteins in 1476 species: Archae - 47; Bacteria - 2960; Metazoa - 10471; Fungi - 4624; Plants - 7423; Viruses - 0; Other Eukaryotes - 847 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      14535506..14537556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129001.3 → NP_180996.1  cytochrome P450, family 710, subfamily A, polypeptide 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180996.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64698, Q8LE78
      UniProtKB/TrEMBL
      A0A178VT37, A0A5S9X4E9, A0A7G2EH64
      Conserved Domains (1) summary
      cd11082
      Location:73 → 485
      CYP61_CYP710; C-22 sterol desaturase subfamily, such as fungal cytochrome P450 61 and plant cytochrome P450 710
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64698.1

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