HUB1 histone mono-ubiquitination 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: HUB1
Official Full Name: histone mono-ubiquitination 1
Primary source: TAIR:AT2G44950
Locus tag: AT2G44950
See related: Araport:AT2G44950
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AT2G44960; histone mono-ubiquitination 1; RDO4; REDUCED DORMANCY 4; T14P1.25; T14P1_25
Summary: The gene encodes one of two orthologous E3 ubiquitin ligases in Arabidopsis that are involved in monoubiquitination of histone H2B.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See HUB1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 20

Sequence:: Chromosome: 2; NC_003071.7 (18542175..18548652, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ATX1 and HUB1/2 promote recruitment of the transcription elongation factor VIP2 to modulate the floral transition in Arabidopsis.
Title: ATX1 and HUB1/2 promote recruitment of the transcription elongation factor VIP2 to modulate the floral transition in Arabidopsis.
Two RING E3 ligases, HISTONE MONOUBIQUITINATION 1 and 2 (HUB1 and HUB2), play a role in the selective transcriptional activation of four cuticle biosynthesis genes in Arabidopsis thaliana.
Title: Histone H2B monoubiquitination is involved in the regulation of cutin and wax composition in Arabidopsis thaliana.
Data showed that parameters for plant fitness are altered in HUB1 mutant and overexpression lines, suggesting that the histone H2B monoubiquitination status affects plant fitness.
Title: Is HUB1 a hub for plant fitness?
Double mutants between hub1-1 and elongata (elo) showed an embryo-lethal phenotype, indicating a synergistic genetic interaction.
Title: Histone H2B monoubiquitination is required to reach maximal transcript levels of circadian clock genes in Arabidopsis.
Results describe the role of the Arabidopsis thaliana RING E3 ligase, HISTONE MONOUBIQUITINATION1 (HUB1) in disease resistance.
Title: HISTONE MONOUBIQUITINATION1 interacts with a subunit of the mediator complex and regulates defense against necrotrophic fungal pathogens in Arabidopsis.
HUB1 upregulates the expression of FLC, and interacts with UBC1 and UBC2 to repress flowering.
Title: Repression of the floral transition via histone H2B monoubiquitination.
Data show that HUB1 is a functional homolog of the human and yeast BRE1 proteins, adn suggest that it mediates gene activation and cell cycle regulation through chromatin modifications.
Title: The Arabidopsis thaliana homolog of yeast BRE1 has a function in cell cycle regulation during early leaf and root growth.
role is proposed for chromatin remodeling in seed dormancy by H2B monoubiquitination through HUB1 and HUB2
Title: The absence of histone H2B monoubiquitination in the Arabidopsis hub1 (rdo4) mutant reveals a role for chromatin remodeling in seed dormancy.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_001337108.1

Supported by ESTs:

NM_130060.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables histone H2B deubiquitinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone ubiquitin ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innate immune response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within leaf morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein monoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of timing of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seed dormancy process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

Go to the top of the page Help

Preferred Names: histone mono-ubiquitination 1

NP_182022.2

histone mono-ubiquitination 1 (HUB1); FUNCTIONS IN: ubiquitin-protein ligase activity, protein homodimerization activity, zinc ion binding; INVOLVED IN: in 10 processes; LOCATED IN: mitochondrion, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type, conserved site (InterPro:IPR017907), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: histone mono-ubiquitination 2 (TAIR:AT1G55250.1); Has 39567 Blast hits to 24086 proteins in 1905 species: Archae - 719; Bacteria - 4806; Metazoa - 20260; Fungi - 3821; Plants - 2415; Viruses - 125; Other Eukaryotes - 7421 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

18542175..18548652 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_130060.4 → NP_182022.2 histone mono-ubiquitination 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_182022.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O22156, O22157, Q8RXD6

UniProtKB/TrEMBL

A0A178VUC4, A0A5S9X732, A0A654F208

Conserved Domains (2) summary

COG1196
Location:286 → 825

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd16499
Location:824 → 865

RING-HC_BRE1_like; RING finger, HC subclass, found in yeast Bre1 and its homologs from eukaryotes
NM_001337108.1 → NP_001323852.1 histone mono-ubiquitination 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8AYB9