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    FUS12 proteasome family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817241, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FUS12
    Official Full Name
    proteasome family protein
    Primary source
    TAIR:AT2G26990
    Locus tag
    AT2G26990
    See related
    Araport:AT2G26990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCSN2; CONSTITUTIVE PHOTOMORPHOGENIC 12; COP12; CSN2; FUSCA 12; T20P8.4; T20P8_4
    Summary
    Represses photomorphogenesis and induces skotomorphogenesis in the dark.
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    Genomic context

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    See FUS12 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (11519388..11522616, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Ctr copper transporter family Neighboring gene CBL-interacting protein kinase 3 Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 8 Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CSN1 N-terminal-dependent activity is required for Arabidopsis development but not for Rub1/Nedd8 deconjugation of cullins: a structure-function study of CSN1 subunit of COP9 signalosome. Wang X, et al. Mol Biol Cell, 2002 Feb. PMID 11854419, Free PMC Article
    2. Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Schwechheimer C, et al. Science, 2001 May 18. PMID 11337587
    3. SMALL ACIDIC PROTEIN1 acts with RUB modification components, the COP9 signalosome, and AXR1 to regulate growth and development of Arabidopsis. Nakasone A, et al. Plant Physiol, 2012 Sep. PMID 22576848, Free PMC Article
    4. The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development. Gusmaroli G, et al. Plant Cell, 2004 Nov. PMID 15486099, Free PMC Article
    5. The COP9 signalosome: from light signaling to general developmental regulation and back. Karniol B, et al. Curr Opin Plant Biol, 2000 Oct. PMID 11019806

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_128257.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within photomorphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteasome family protein
    NP_565632.1
    • FUSCA 12 (FUS12); INVOLVED IN: cullin deneddylation, photomorphogenesis, protein catabolic process; LOCATED IN: signalosome, nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Proteasome component (PCI) domain (InterPro:IPR000717), PCI/PINT associated module (InterPro:IPR013143); BEST Arabidopsis thaliana protein match is: non-ATPase subunit 9 (TAIR:AT1G29150.1); Has 881 Blast hits to 877 proteins in 239 species: Archae - 2; Bacteria - 9; Metazoa - 323; Fungi - 235; Plants - 190; Viruses - 0; Other Eukaryotes - 122 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11519388..11522616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128257.4 → NP_565632.1  proteasome family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565632.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8W207, Q94A24, Q9ZVD8
      UniProtKB/TrEMBL
      A0A178VSH3, A0A5S9X1R9
      Conserved Domains (2) summary
      COG5159
      Location:65 → 406
      RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:305 → 405
      PCI; PCI domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W207.1

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