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    PS1 Presenilin-1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837391, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PS1
    Official Full Name
    Presenilin-1
    Primary source
    TAIR:AT1G08700
    Locus tag
    AT1G08700
    See related
    Araport:AT1G08700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22O13.18; F22O13_18; Presenilin-1
    Summary
    Encodes a protein similar to animal presenilin whose expression is increased in response to potassium (K+) deprivation.
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    Genomic context

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    See PS1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (2769615..2771477, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ENTH/VHS family protein Neighboring gene ARF GAP-like zinc finger-containing protein ZIGA4 Neighboring gene SCR-like 3 Neighboring gene F-box family protein Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Organelles maintain spindle position in plant meiosis. Brownfield L, et al. Nat Commun, 2015 Mar 11. PMID 25757555
    2. Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana. Smolarkiewicz M, et al. J Exp Bot, 2014 Jul. PMID 24723404, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_100743.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi-associated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Presenilin-1
    NP_172346.1
    • Presenilin-1 (PS1); INVOLVED IN: intracellular signaling pathway; LOCATED IN: endomembrane system, integral to membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase A22, presenilin signal peptide (InterPro:IPR006639), Peptidase A22A, presenilin (InterPro:IPR001108); BEST Arabidopsis thaliana protein match is: Presenilin-2 (TAIR:AT2G29900.1); Has 596 Blast hits to 445 proteins in 109 species: Archae - 4; Bacteria - 0; Metazoa - 417; Fungi - 0; Plants - 68; Viruses - 0; Other Eukaryotes - 107 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2769615..2771477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100743.4 → NP_172346.1  Presenilin-1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172346.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64668, Q8L9V0
      UniProtKB/TrEMBL
      A0A178W198, A0A384LEN8, Q0V7S4
      Conserved Domains (1) summary
      pfam01080
      Location:10 → 443
      Presenilin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64668.1

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