PP2A serine/threonine protein phosphatase 2A [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PP2A
Official Full Name: serine/threonine protein phosphatase 2A
Primary source: TAIR:AT1G69960
Locus tag: AT1G69960
See related: Araport:AT1G69960
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F20P5.30; F20P5_30; serine/threonine protein phosphatase 2A; TYPE 2A SERINE/THREONINE PROTEIN PHOSPHATASE
Summary: type 2A serine/threonine protein phosphatase (PP2A) mRNA
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Genomic context

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See PP2A in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 5

Sequence:: Chromosome: 1; NC_003070.9 (26348721..26350697, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct Clades of Protein Phosphatase 2A Regulatory B'/B56 Subunits Engage in Different Physiological Processes.
Title: Distinct Clades of Protein Phosphatase 2A Regulatory B'/B56 Subunits Engage in Different Physiological Processes.
The role of protein phosphatase 2A (PP2A) in the unfolded protein response (UPR) of plants.
Title: The role of protein phosphatase 2A (PP2A) in the unfolded protein response (UPR) of plants.
The B'zeta subunit of protein phosphatase 2A negatively regulates ethylene signaling in Arabidopsis.
Title: The B'ζ subunit of protein phosphatase 2A negatively regulates ethylene signaling in Arabidopsis.
The B''-family subunits of protein phosphatase 2A are necessary for in-vitro dephosphorylation of the Arabidopsis mechanosensory transcription factor VIP1.
Title: The B″-family subunits of protein phosphatase 2A are necessary for in-vitro dephosphorylation of the Arabidopsis mechanosensory transcription factor VIP1.
PROTEIN PHOSPHATASE 2A-B'gamma Controls Botrytis cinerea Resistance and Developmental Leaf Senescence.
Title: PROTEIN PHOSPHATASE 2A-B'γ Controls Botrytis cinerea Resistance and Developmental Leaf Senescence.
Protein phosphatase 2A alleviates cadmium toxicity by modulating ethylene production in Arabidopsis thaliana.
Title: Protein phosphatase 2A alleviates cadmium toxicity by modulating ethylene production in Arabidopsis thaliana.
Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants.
Title: Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants.
Protein phosphatase 2A promotes stomatal development by stabilizing SPEECHLESS in Arabidopsis.
Title: Protein phosphatase 2A promotes stomatal development by stabilizing SPEECHLESS in Arabidopsis.
Protein phosphatase 2A regulates the nuclear accumulation of the Arabidopsis bZIP protein VIP1 under hypo-osmotic stress.
Title: Protein phosphatase 2A regulates the nuclear accumulation of the Arabidopsis bZIP protein VIP1 under hypo-osmotic stress.
Transgenic Arabidopsis plants expressing both AVP1 and PP2A-C5 at relatively high levels were identified and analyzed. These plants displayed enhanced tolerance to NaCl compared to either AVP1 or PP2A-C5 overexpressing plants.
Title: Co-overexpression of AVP1 and PP2A-C5 in Arabidopsis makes plants tolerant to multiple abiotic stresses.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_105665.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of auxin polar transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: serine/threonine protein phosphatase 2A

NP_177154.1

serine/threonine protein phosphatase 2A (PP2A); CONTAINS InterPro DOMAIN/s: Metallophosphoesterase (InterPro:IPR004843), Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (InterPro:IPR006186); BEST Arabidopsis thaliana protein match is: protein phosphatase 2A-2 (TAIR:AT1G10430.1); Has 6844 Blast hits to 6656 proteins in 515 species: Archae - 80; Bacteria - 271; Metazoa - 2385; Fungi - 1410; Plants - 969; Viruses - 4; Other Eukaryotes - 1725 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

26348721..26350697 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_105665.3 → NP_177154.1 serine/threonine protein phosphatase 2A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_177154.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O04951, Q1EC63, Q42544

UniProtKB/TrEMBL

A0A178WFY3, A0A5S9WT90, A0A7G2E239

Conserved Domains (1) summary

cd07415
Location:7 → 291

MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain