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    BON3 Calcium-dependent phospholipid-binding Copine family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837408, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BON3
    Official Full Name
    Calcium-dependent phospholipid-binding Copine family protein
    Primary source
    TAIR:AT1G08860
    Locus tag
    AT1G08860
    See related
    Araport:AT1G08860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BONZAI 3; F7G19.25; F7G19_25
    Summary
    Encodes a copine-like protein, which is a member of a newly identified class of calcium-dependent, phospholipid binding proteins that are present in a wide range of organisms. Overexpression of this gene suppresses bon1-1 phenotypes. Double mutant analyses with bon1-1 suggest that BON1 and BON3 have overlapping functions in maintaining cellular homeostasis and inhibiting cell death.
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    Genomic context

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    See BON3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    16
    Sequence:
    Chromosome: 1; NC_003070.9 (2841969..2846350)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene copper/zinc superoxide dismutase 1 Neighboring gene DNA replication helicase Neighboring gene Ribosomal L18p/L5e family protein Neighboring gene tRNA-Ala Neighboring gene Histone superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple R-like genes are negatively regulated by BON1 and BON3 in arabidopsis. Li Y, et al. Mol Plant Microbe Interact, 2009 Jul. PMID 19522566
    2. BON1 interacts with the protein kinases BIR1 and BAK1 in modulation of temperature-dependent plant growth and cell death in Arabidopsis. Wang Z, et al. Plant J, 2011 Sep. PMID 21623975
    3. Opposing Effects on Two Phases of Defense Responses from Concerted Actions of HEAT SHOCK COGNATE70 and BONZAI1 in Arabidopsis. Gou M, et al. Plant Physiol, 2015 Nov. PMID 26408532, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipid binding NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular homeostasis NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cellular defense response NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Calcium-dependent phospholipid-binding Copine family protein
    NP_172362.3
    • BONZAI 3 (BON3); FUNCTIONS IN: calcium-dependent phospholipid binding; INVOLVED IN: N-terminal protein myristoylation, cellular homeostasis, positive regulation of cellular defense response, negative regulation of cell death; EXPRESSED IN: sperm cell, male gametophyte, flower, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Copine (InterPro:IPR010734), C2 calcium-dependent membrane targeting (InterPro:IPR000008), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: DCD (Development and Cell Death) domain protein (TAIR:AT5G61910.4); Has 1559 Blast hits to 1479 proteins in 107 species: Archae - 0; Bacteria - 0; Metazoa - 903; Fungi - 12; Plants - 319; Viruses - 0; Other Eukaryotes - 325 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2841969..2846350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100759.4 → NP_172362.3  Calcium-dependent phospholipid-binding Copine family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172362.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04042, Q1KS96, Q5XQC7
      UniProtKB/TrEMBL
      A0A178WMW0, A0A5S9TED8
      Conserved Domains (3) summary
      cd04047
      Location:197 → 302
      C2B_Copine; C2 domain second repeat in Copine
      cd04048
      Location:52 → 177
      C2A_Copine; C2 domain first repeat in Copine
      cd01459
      Location:312 → 567
      vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XQC7.1

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