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    HDG2 homeodomain GLABROUS 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839256, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HDG2
    Official Full Name
    homeodomain GLABROUS 2
    Primary source
    TAIR:AT1G05230
    Locus tag
    AT1G05230
    See related
    Araport:AT1G05230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    homeodomain GLABROUS 2; YUP8H12.16; YUP8H12_16
    Summary
    Encodes a homeobox-leucine zipper family protein belonging to the HD-ZIP IV family. Mutants have trichomes that appear glass-like under a dissecting microscope as compared to the wild-type trichomes. The mutations do not affect trichome growth or branch number.
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    Genomic context

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    See HDG2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (1512896..1518900, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Transmembrane protein 97, Putative Neighboring gene Transmembrane protein 97, Putative Neighboring gene ncRNA Neighboring gene Peroxidase superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HOMEODOMAIN GLABROUS2 regulates cellulose biosynthesis in seed coat mucilage by activating CELLULOSE SYNTHASE5. Kong Y, et al. Plant Physiol, 2021 Feb 25. PMID 33631797, Free PMC Article
    2. Arabidopsis homeodomain-leucine zipper IV proteins promote stomatal development and ectopically induce stomata beyond the epidermis. Peterson KM, et al. Development, 2013 May. PMID 23515473, Free PMC Article
    3. Mutations in epidermis-specific HD-ZIP IV genes affect floral organ identity in Arabidopsis thaliana. Kamata N, et al. Plant J, 2013 Aug. PMID 23590515
    4. Transcriptome analysis of Arabidopsis wild-type and gl3-sst sim trichomes identifies four additional genes required for trichome development. Marks MD, et al. Mol Plant, 2009 Jul. PMID 19626137, Free PMC Article
    5. AIL and HDG proteins act antagonistically to control cell proliferation. Horstman A, et al. Development, 2015 Feb 1. PMID 25564655

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HDG2 is involved in determining the identity of petals and stamens.
      Title: Mutations in epidermis-specific HD-ZIP IV genes affect floral organ identity in Arabidopsis thaliana.
    2. HDG2 overexpression confers differentiation of ectopic stomata in internal mesophyll tissues.
      Title: Arabidopsis homeodomain-leucine zipper IV proteins promote stomatal development and ectopically induce stomata beyond the epidermis.
    3. HDG2 gene is required for normal gl3-sst sim trichome development.
      Title: Transcriptome analysis of Arabidopsis wild-type and gl3-sst sim trichomes identifies four additional genes required for trichome development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001123759.1
    NM_001197982.1
    NM_001331528.1
    NM_001331529.1
    NM_001331530.1
    NM_001331531.1
    NM_001331532.1
    NM_001331533.1
    NM_001331534.1
    NM_001331535.1
    NM_100402.3
    NM_179265.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within maintenance of floral organ identity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maintenance of floral organ identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mucilage biosynthetic process involved in seed coat development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in plant-type cell wall cellulose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within seed coat development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    homeodomain GLABROUS 2
    NP_001117231.1
    • homeodomain GLABROUS 2 (HDG2); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, trichome morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 32 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox, conserved site (InterPro:IPR017970), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: protodermal factor 2 (TAIR:AT4G04890.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_001184911.1
    • homeodomain GLABROUS 2 (HDG2); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, trichome morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 32 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox, conserved site (InterPro:IPR017970), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: protodermal factor 2 (TAIR:AT4G04890.1).
    NP_172015.1
    • homeodomain GLABROUS 2 (HDG2); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, trichome morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 32 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox, conserved site (InterPro:IPR017970), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: protodermal factor 2 (TAIR:AT4G04890.1); Has 8730 Blast hits to 8651 proteins in 460 species: Archae - 0; Bacteria - 0; Metazoa - 6110; Fungi - 222; Plants - 2153; Viruses - 0; Other Eukaryotes - 245 (source: NCBI BLink).
    NP_849596.1
    • homeodomain GLABROUS 2 (HDG2); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent, trichome morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 32 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox, conserved site (InterPro:IPR017970), Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: protodermal factor 2 (TAIR:AT4G04890.1); Has 8732 Blast hits to 8653 proteins in 460 species: Archae - 0; Bacteria - 0; Metazoa - 6111; Fungi - 223; Plants - 2153; Viruses - 0; Other Eukaryotes - 245 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1512896..1518900 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001123759.1 → NP_001117231.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001117231.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WDY9, B3H6Y4
      Conserved Domains (3) summary
      cd08875
      Location:246 → 464
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      pfam00046
      Location:67 → 120
      Homeobox; Homeobox domain
      cl19252
      Location:130 → 202
      MreC; rod shape-determining protein MreC

    2. NM_179265.2 → NP_849596.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849596.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23045, Q94C37
      UniProtKB/TrEMBL
      A0A178WE21, A0A5S9SPD3, B9DFH8
      Conserved Domains (2) summary
      cd08875
      Location:246 → 464
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      pfam00046
      Location:67 → 121
      Homeobox; Homeobox domain

    3. NM_001197982.1 → NP_001184911.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184911.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23045, Q94C37
      UniProtKB/TrEMBL
      A0A178WE21, A0A5S9SPD3, B9DFH8
      Conserved Domains (2) summary
      cd08875
      Location:246 → 464
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      pfam00046
      Location:67 → 121
      Homeobox; Homeobox domain

    4. NM_100402.3 → NP_172015.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172015.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23045, Q94C37
      UniProtKB/TrEMBL
      A0A178WE21, A0A5S9SPD3, B9DFH8
      Conserved Domains (2) summary
      cd08875
      Location:246 → 464
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      pfam00046
      Location:67 → 121
      Homeobox; Homeobox domain

    5. NM_001331528.1 → NP_001322680.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23045, Q94C37
      UniProtKB/TrEMBL
      A0A178WE21, A0A5S9SPD3, B9DFH8
      Conserved Domains (2) summary
      cd08875
      Location:246 → 464
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      pfam00046
      Location:67 → 121
      Homeobox; Homeobox domain

    6. NM_001331533.1 → NP_001322675.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23045, Q94C37
      UniProtKB/TrEMBL
      A0A178WE21, A0A5S9SPD3, B9DFH8
      Conserved Domains (2) summary
      cd08875
      Location:246 → 464
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      pfam00046
      Location:67 → 121
      Homeobox; Homeobox domain

    7. NM_001331532.1 → NP_001322674.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23045, Q94C37
      UniProtKB/TrEMBL
      A0A178WE21, A0A5S9SPD3, B9DFH8
      Conserved Domains (2) summary
      cd08875
      Location:246 → 464
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      pfam00046
      Location:67 → 121
      Homeobox; Homeobox domain

    8. NM_001331531.1 → NP_001322673.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23045, Q94C37
      UniProtKB/TrEMBL
      A0A178WE21, A0A5S9SPD3, B9DFH8
      Conserved Domains (2) summary
      cd08875
      Location:246 → 464
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      pfam00046
      Location:67 → 121
      Homeobox; Homeobox domain

    9. NM_001331529.1 → NP_001322678.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23045, Q94C37
      UniProtKB/TrEMBL
      A0A178WE21, A0A5S9SPD3, B9DFH8
      Conserved Domains (2) summary
      cd08875
      Location:246 → 464
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      pfam00046
      Location:67 → 121
      Homeobox; Homeobox domain

    10. NM_001331535.1 → NP_001322677.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23045, Q94C37
      UniProtKB/TrEMBL
      A0A178WE21, A0A5S9SPD3, B9DFH8
      Conserved Domains (2) summary
      cd08875
      Location:246 → 464
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      pfam00046
      Location:67 → 121
      Homeobox; Homeobox domain

    11. NM_001331534.1 → NP_001322676.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23045, Q94C37
      UniProtKB/TrEMBL
      A0A178WE21, A0A5S9SPD3, B9DFH8
      Conserved Domains (2) summary
      cd08875
      Location:246 → 464
      START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins
      pfam00046
      Location:67 → 121
      Homeobox; Homeobox domain

    12. NM_001331530.1 → NP_001322679.1  homeodomain GLABROUS 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WE21, A0A1P8AUV2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94C37.1

    Gene LinkOut

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