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    ARF3 ADP-ribosylation factor 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817014, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARF3
    Official Full Name
    ADP-ribosylation factor 3
    Primary source
    TAIR:AT2G24765
    Locus tag
    AT2G24765
    See related
    Araport:AT2G24765
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ADP-ribosylation factor 3; ARF-LIKE 1; ARL1; ATARL1; F27A10.8
    Summary
    GTPase required for Golgi targeting of GRIP domain proteins. AtARL1 binds directly to the GRIP domain of AtGRIP in a GTP-dependent manner
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    Genomic context

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    See ARF3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (10562688..10565296)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene glutamine dumper 4 Neighboring gene uncharacterized protein Neighboring gene CONSTANS-like 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AUXIN RESPONSE FACTOR3 Regulates Floral Meristem Determinacy by Repressing Cytokinin Biosynthesis and Signaling. Zhang K, et al. Plant Cell, 2018 Feb. PMID 29371438, Free PMC Article
    2. tasiRNA-ARF pathway moderates floral architecture in Arabidopsis plants subjected to drought stress. Matsui A, et al. Biomed Res Int, 2014. PMID 25243128, Free PMC Article
    3. Pattern of auxin and cytokinin responses for shoot meristem induction results from the regulation of cytokinin biosynthesis by AUXIN RESPONSE FACTOR3. Cheng ZJ, et al. Plant Physiol, 2013 Jan. PMID 23124326, Free PMC Article
    4. ARF3-Mediated Regulation of SPL in Early Anther Morphogenesis: Maintaining Precise Spatial Distribution and Expression Level. Yang Q, et al. Int J Mol Sci, 2023 Jul 21. PMID 37511499, Free PMC Article
    5. ARL1 plays a role in the binding of the GRIP domain of a peripheral matrix protein to the Golgi apparatus in plant cells. Stefano G, et al. Plant Mol Biol, 2006 Jun. PMID 16830178

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARF3-Mediated Regulation of SPL in Early Anther Morphogenesis: Maintaining Precise Spatial Distribution and Expression Level.
      Title: ARF3-Mediated Regulation of SPL in Early Anther Morphogenesis: Maintaining Precise Spatial Distribution and Expression Level.
    2. Regulation of Female Germline Specification via Small RNA Mobility in Arabidopsis.
      Title: Regulation of Female Germline Specification via Small RNA Mobility in Arabidopsis.
    3. ARF3 controls cell division by regulating cell cycle gene expression through cytokinin.
      Title: AUXIN RESPONSE FACTOR3 Regulates Floral Meristem Determinacy by Repressing Cytokinin Biosynthesis and Signaling.
    4. AS2, RH10 and NUC1 maintain cytosine methylations at specific sets of CpG sites in exon 6 of ARF3.
      Title: Arabidopsis Zinc-Finger-Like Protein ASYMMETRIC LEAVES2 (AS2) and Two Nucleolar Proteins Maintain Gene Body DNA Methylation in the Leaf Polarity Gene ETTIN (ARF3).
    5. Results indicate that auxin response factors AtARF2-AtARF4 and AtARF5 play significant roles in regulating both female and male gametophyte development.
      Title: ARF2-ARF4 and ARF5 are Essential for Female and Male Gametophyte Development in Arabidopsis.
    6. Analysis of ta-siRNA synthesis mutants and mutated ARF3-overexpressing plants that escape the tasiRNA-ARF target indicated that self-pollination was hampered by short stamens in plants under drought and high-salinity stress.
      Title: tasiRNA-ARF pathway moderates floral architecture in Arabidopsis plants subjected to drought stress.
    7. ARF3 is a direct target of AP2 and partially mediates AP2's function in floral meristem determinacy.ARF3 integrates the functions of AGAMOUS and APETALA2 in floral meristem determinacy.
      Title: AUXIN RESPONSE FACTOR 3 integrates the functions of AGAMOUS and APETALA2 in floral meristem determinacy.
    8. ARF3 mediates the auxin response during de novo shoot regeneration.
      Title: Pattern of auxin and cytokinin responses for shoot meristem induction results from the regulation of cytokinin biosynthesis by AUXIN RESPONSE FACTOR3.
    9. AS1 binds the ETT promoter. An upstream region of ETT directs transcriptional repression by AS1 and AS2. AS2 requires AS1 to regulate ETT expression directly.
      Title: Dual regulation of ETTIN (ARF3) gene expression by AS1-AS2, which maintains the DNA methylation level, is involved in stabilization of leaf adaxial-abaxial partitioning in Arabidopsis.
    10. ARL1(AT2G24765) is associated with the localization of peripheral golgins to the plant Golgi apparatus.
      Title: ARL1 plays a role in the binding of the GRIP domain of a peripheral matrix protein to the Golgi apparatus in plant cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084486.1
    NM_179726.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    ADP-ribosylation factor 3
    NP_001077955.1
    • ADP-ribosylation factor 3 (ARF3); FUNCTIONS IN: protein binding; INVOLVED IN: N-terminal protein myristoylation; LOCATED IN: Golgi stack, plasma membrane, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ADP-ribosylation factor (InterPro:IPR006688), ARF/SAR superfamily (InterPro:IPR006689); BEST Arabidopsis thaliana protein match is: ADP-ribosylation factor A1B (TAIR:AT5G14670.1); Has 9110 Blast hits to 9109 proteins in 393 species: Archae - 2; Bacteria - 4; Metazoa - 4531; Fungi - 1457; Plants - 1456; Viruses - 3; Other Eukaryotes - 1657 (source: NCBI BLink).
    NP_850057.1
    • ADP-ribosylation factor 3 (ARF3); FUNCTIONS IN: protein binding; INVOLVED IN: response to cadmium ion, N-terminal protein myristoylation; LOCATED IN: Golgi stack, plasma membrane, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: ADP-ribosylation factor (InterPro:IPR006688), Small GTP-binding protein (InterPro:IPR005225), Small GTPase SAR1-type (InterPro:IPR006687), ARF/SAR superfamily (InterPro:IPR006689); BEST Arabidopsis thaliana protein match is: ADP-ribosylation factor A1B (TAIR:AT5G14670.1); Has 11503 Blast hits to 11498 proteins in 430 species: Archae - 12; Bacteria - 8; Metazoa - 5738; Fungi - 1713; Plants - 1591; Viruses - 3; Other Eukaryotes - 2438 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10562688..10565296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179726.3 → NP_850057.1  ADP-ribosylation factor 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850057.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MRA0, P40940, Q541X9
      UniProtKB/TrEMBL
      A0A178VQT4, A0A5S9X179
      Conserved Domains (1) summary
      cd04151
      Location:19 → 176
      Arl1; ADP ribosylation factor 1 (Arf1)

    2. NM_001084486.1 → NP_001077955.1  ADP-ribosylation factor 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077955.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40940
      Conserved Domains (1) summary
      cl21455
      Location:19 → 128
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40940.2

    Gene LinkOut

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