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    AGL61 AGAMOUS-like 61 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817021, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AGL61
    Official Full Name
    AGAMOUS-like 61
    Primary source
    TAIR:AT2G24840
    Locus tag
    AT2G24840
    See related
    Araport:AT2G24840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AGAMOUS-like 61; DIA; DIANA; F27C12.24; F27C12_24
    Summary
    Encodes a member of the Agamous-like family of transcription factors. Localized to the nucleus in the central cell and endosperm of the female gametophyte. Loss of function mutations show reduced female fertility. Fifty percent of ovules have defective central cells with abnormal morphology and patterns of gene expression. Upon fertilization 50% of seeds abort. Using yeast two hybrid assays AGL61 was shown to interact with AGL80, another MADS box gene with similar defects in ovule development. These data suggest that AGL61 and 80 together are required for proper differentiation of the central cell.
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    Genomic context

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    See AGL61 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (10581069..10582015)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene translocon at the inner envelope membrane of chloroplasts 55-II Neighboring gene ncRNA Neighboring gene zinc finger (CCCH-type) family protein / D111/G-patch domain-containing protein Neighboring gene tyrosine aminotransferase 3 Neighboring gene DnaJ/Hsp40 cysteine-rich domain superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MADS domain protein DIANA acts together with AGAMOUS-LIKE80 to specify the central cell in Arabidopsis ovules. Bemer M, et al. Plant Cell, 2008 Aug. PMID 18713950, Free PMC Article
    2. AGL61 interacts with AGL80 and is required for central cell development in Arabidopsis. Steffen JG, et al. Plant Physiol, 2008 Sep. PMID 18599653, Free PMC Article
    3. Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world. Parenicová L, et al. Plant Cell, 2003 Jul. PMID 12837945, Free PMC Article
    4. Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays. Popescu SC, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360592, Free PMC Article
    5. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Riechmann JL, et al. Science, 2000 Dec 15. PMID 11118137

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that AGL61 and AGL80 appear to function together to differentiate the central cell in Arabidopsis. Data renamed AGL61 DIANA, after the virginal Roman goddess of the hunt.
      Title: The MADS domain protein DIANA acts together with AGAMOUS-LIKE80 to specify the central cell in Arabidopsis ovules.
    2. controls the expression of downstream genes during central cell development
      Title: AGL61 interacts with AGL80 and is required for central cell development in Arabidopsis.
    3. DIANA (AGL61) forms a complex with AGL80 to specify the central cell in Arabidopsis ovules. [AGL61] [DIANA]
      Title: The MADS domain protein DIANA acts together with AGAMOUS-LIKE80 to specify the central cell in Arabidopsis ovules.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_179727.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo sac central cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in polar nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AGAMOUS-like 61
    NP_850058.1
    • AGAMOUS-like 61 (AGL61); CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100); BEST Arabidopsis thaliana protein match is: AGAMOUS-like 62 (TAIR:AT5G60440.1); Has 5781 Blast hits to 5781 proteins in 683 species: Archae - 0; Bacteria - 0; Metazoa - 624; Fungi - 302; Plants - 4788; Viruses - 0; Other Eukaryotes - 67 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10581069..10582015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179727.5 → NP_850058.1  AGAMOUS-like 61 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850058.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4PSU4, Q9SK48
      Conserved Domains (1) summary
      cd00265
      Location:63 → 130
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4PSU4.1

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