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    QKY C2 calcium/lipid-binding plant phosphoribosyltransferase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843811, updated on 18-Sep-2024

    Summary

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    Official Symbol
    QKY
    Official Full Name
    C2 calcium/lipid-binding plant phosphoribosyltransferase family protein
    Primary source
    TAIR:AT1G74720
    Locus tag
    AT1G74720
    See related
    Araport:AT1G74720
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F25A4.35; F25A4_35; QUIRKY
    Summary
    Encodes a putative transmembrane protein carrying four C(2) domains, suggesting that QKY may function in membrane trafficking in a Ca(2+)-dependent fashion. Mutant analysis shows that this gene is involved in organ development.
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    Genomic context

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    See QKY in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (28074927..28078831)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene tRNAse Z1 Neighboring gene ADC synthase superfamily protein Neighboring gene transmembrane protein, putative (DUF1118) Neighboring gene ncRNA Neighboring gene calcium-dependent protein kinase 30

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis MCTP family member QUIRKY regulates the formation of the STRUBBELIG receptor kinase complex. Chen X, et al. Plant Physiol, 2023 Nov 22. PMID 37668394
    2. The C2-domain protein QUIRKY and the receptor-like kinase STRUBBELIG localize to plasmodesmata and mediate tissue morphogenesis in Arabidopsis thaliana. Vaddepalli P, et al. Development, 2014 Nov. PMID 25256344
    3. DETORQUEO, QUIRKY, and ZERZAUST represent novel components involved in organ development mediated by the receptor-like kinase STRUBBELIG in Arabidopsis thaliana. Fulton L, et al. PLoS Genet, 2009 Jan. PMID 19180193, Free PMC Article
    4. QUIRKY interacts with STRUBBELIG and PAL OF QUIRKY to regulate cell growth anisotropy during Arabidopsis gynoecium development. Trehin C, et al. Development, 2013 Dec. PMID 24173806
    5. Characterization of Multiple C2 Domain and Transmembrane Region Proteins in Arabidopsis. Liu L, et al. Plant Physiol, 2018 Mar. PMID 29259105, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis MCTP family member QUIRKY regulates the formation of the STRUBBELIG receptor kinase complex.
      Title: Arabidopsis MCTP family member QUIRKY regulates the formation of the STRUBBELIG receptor kinase complex.
    2. The C2-domain protein QUIRKY and the receptor-like kinase STRUBBELIG localize to plasmodesmata and mediate tissue morphogenesis in Arabidopsis thaliana
      Title: The C2-domain protein QUIRKY and the receptor-like kinase STRUBBELIG localize to plasmodesmata and mediate tissue morphogenesis in Arabidopsis thaliana.
    3. QKY is localised at the plasma membrane and functions in a multiprotein complex that includes SUB and PAL OF QUIRKY (POQ), a previously uncharacterised PB1-domain-containing protein that localizes both at the plasma membrane and in intracellular compartments. [POQ]
      Title: QUIRKY interacts with STRUBBELIG and PAL OF QUIRKY to regulate cell growth anisotropy during Arabidopsis gynoecium development.
    4. QKY is localized at the plasma membrane and functions in a multiprotein complex that includes SUB and PAL OF QUIRKY, a previously uncharacterized PB1-domain-containing protein that localizes both at the plasma membrane and in intracellular compartments.
      Title: QUIRKY interacts with STRUBBELIG and PAL OF QUIRKY to regulate cell growth anisotropy during Arabidopsis gynoecium development.
    5. DETORQEO (DOQ), QUIRKY (QKY), and ZERZAUST (ZET)contribute to leucine-rich repeat receptor-like kinase STRUBBELIG(SUB)-dependent organogenesis. [QKY] [QUIRKY]
      Title: DETORQUEO, QUIRKY, and ZERZAUST represent novel components involved in organ development mediated by the receptor-like kinase STRUBBELIG in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_106130.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anisotropic cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gynoecium development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasmodesmata-mediated intercellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 
    located_in plasmodesma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C2 calcium/lipid-binding plant phosphoribosyltransferase family protein
    NP_177610.1
    • QUIRKY (QKY); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: organ development; LOCATED IN: plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phosphoribosyltransferase C-terminal (InterPro:IPR013583), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: C2 calcium/lipid-binding plant phosphoribosyltransferase family protein (TAIR:AT4G11610.1); Has 6147 Blast hits to 4985 proteins in 369 species: Archae - 2; Bacteria - 143; Metazoa - 2968; Fungi - 627; Plants - 1368; Viruses - 31; Other Eukaryotes - 1008 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      28074927..28078831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106130.7 → NP_177610.1  C2 calcium/lipid-binding plant phosphoribosyltransferase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177610.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B8XCH5, Q0WLK0, Q9CA47, Q9SSF7
      UniProtKB/TrEMBL
      A0A178W8C8, A0A5S9WUF1, A0A654EP18
      Conserved Domains (5) summary
      cd04019
      Location:498 → 658
      C2C_MCTP_PRT_plant; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); plant subset
      cd04022
      Location:18 → 148
      C2A_MCTP_PRT_plant; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); plant subset
      cd08378
      Location:336 → 466
      C2B_MCTP_PRT_plant; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); plant subset
      cd08379
      Location:670 → 797
      C2D_MCTP_PRT_plant; C2 domain fourth repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); plant subset
      pfam08372
      Location:926 → 1080
      PRT_C; Plant phosphoribosyltransferase C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B8XCH5.1

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