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    4CL3 4-coumarate:CoA ligase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842814, updated on 18-Sep-2024

    Summary

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    Official Symbol
    4CL3
    Official Full Name
    4-coumarate:CoA ligase 3
    Primary source
    TAIR:AT1G65060
    Locus tag
    AT1G65060
    See related
    Araport:AT1G65060
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    4-COUMARATE:COA LIGASE; 4-coumarate:CoA ligase 3; F16G16.6; F16G16_6
    Summary
    encodes an isoform of 4-coumarate:CoA ligase (4CL), which is involved in the last step of the general phenylpropanoid pathway. mRNA levels are not induced in response to wounding or to fungal infection by P. parasitica. mRNA is expressed in flowers, to a lesser degree in mature leaves and siliques and marginally in seedling roots and bolting stems of mature plants. The catalytic efficiency was in the following (descending) order: p-coumaric acid, caffeic acid, ferulic acid, cinnamic acid and 5-OH-ferulic acid. At4CL3 was unable to use sinapic acid as substrate.
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    Genomic context

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    See 4CL3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (24167202..24171635, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene TRAF-like superfamily protein Neighboring gene DNA mismatch repair protein MutS, type 2 Neighboring gene Membrane insertion protein, OxaA/YidC with tetratricopeptide repeat domain-containing protein Neighboring gene nucleolin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Three 4-coumarate:coenzyme A ligases in Arabidopsis thaliana represent two evolutionarily divergent classes in angiosperms. Ehlting J, et al. Plant J, 1999 Jul. PMID 10417722
    2. A large-scale genetic screen in Arabidopsis to identify genes involved in pollen exine production. Dobritsa AA, et al. Plant Physiol, 2011 Oct. PMID 21849515, Free PMC Article
    3. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_105180.4
    NM_179513.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 4-coumarate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in defense response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within phenylpropanoid metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen exine formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    NOT involved_in response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    4-coumarate:CoA ligase 3
    NP_176686.1
    • 4-coumarate:CoA ligase 3 (4CL3); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: 4-coumarate:CoA ligase 2 (TAIR:AT3G21240.1); Has 85516 Blast hits to 77968 proteins in 3765 species: Archae - 1155; Bacteria - 54010; Metazoa - 3516; Fungi - 4668; Plants - 2834; Viruses - 1; Other Eukaryotes - 19332 (source: NCBI BLink).
    NP_849844.1
    • 4-coumarate:CoA ligase 3 (4CL3); CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: 4-coumarate:CoA ligase 2 (TAIR:AT3G21240.1); Has 78268 Blast hits to 71395 proteins in 3651 species: Archae - 1111; Bacteria - 51774; Metazoa - 3299; Fungi - 4373; Plants - 2538; Viruses - 1; Other Eukaryotes - 15172 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24167202..24171635 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105180.4 → NP_176686.1  4-coumarate:CoA ligase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176686.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93Z69, Q9S777
      UniProtKB/TrEMBL
      A0A654EL36, A0A7G2E2V1
      Conserved Domains (1) summary
      PLN02246
      Location:26 → 561
      PLN02246; 4-coumarate--CoA ligase

    2. NM_179513.2 → NP_849844.1  4-coumarate:CoA ligase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849844.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2E2V1, F4I9T8
      Conserved Domains (2) summary
      pfam00501
      Location:63 → 465
      AMP-binding; AMP-binding enzyme
      cl17068
      Location:44 → 473
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S777.1

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