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    mMDH1 Lactate/malate dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841757, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mMDH1
    Official Full Name
    Lactate/malate dehydrogenase family protein
    Primary source
    TAIR:AT1G53240
    Locus tag
    AT1G53240
    See related
    Araport:AT1G53240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    mitochondrial malate dehydrogenase 1
    Summary
    mMDH1 encodes a mitochrondrial malate dehydrogenase. It is expressed at higher levels than the other mitochrondrial isoform mMDH2 (At3G15020) according to transcript and proteomic analyses.
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    Genomic context

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    See mMDH1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (19854615..19857146, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene TEOSINTE BRANCHED 1, cycloidea and PCF transcription factor 3 Neighboring gene histone-lysine N-methyltransferase, H3 lysine-79 specific-like protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adenine nucleotide-dependent and redox-independent control of mitochondrial malate dehydrogenase activity in Arabidopsis thaliana. Yoshida K, et al. Biochim Biophys Acta, 2016 Jun. PMID 26946085
    2. Analysis of differential expression patterns of mRNA and protein during cold-acclimation and de-acclimation in Arabidopsis. Nakaminami K, et al. Mol Cell Proteomics, 2014 Dec. PMID 25277243, Free PMC Article
    3. Loss of Mitochondrial Malate Dehydrogenase Activity Alters Seed Metabolism Impairing Seed Maturation and Post-Germination Growth in Arabidopsis. Sew YS, et al. Plant Physiol, 2016 Jun. PMID 27208265, Free PMC Article
    4. Mitochondrial malate dehydrogenase lowers leaf respiration and alters photorespiration and plant growth in Arabidopsis. Tomaz T, et al. Plant Physiol, 2010 Nov. PMID 20876337, Free PMC Article
    5. Plants Possess a Cyclic Mitochondrial Metabolic Pathway similar to the Mammalian Metabolic Repair Mechanism Involving Malate Dehydrogenase and l-2-Hydroxyglutarate Dehydrogenase. Hüdig M, et al. Plant Cell Physiol, 2015 Sep. PMID 26203119

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study has shown that mMDH is an important respiratory element in Arabidopsis seeds, with a significant impact on early seedling growth. Perturbation of both mMDH genes in Arabidopsis seeds significantly elevated respiration rates at all stages of seed maturation, markedly reduced reserve accumulation, and accelerated the aging process in seeds.
      Title: Loss of Mitochondrial Malate Dehydrogenase Activity Alters Seed Metabolism Impairing Seed Maturation and Post-Germination Growth in Arabidopsis.
    2. Results suggest that mitochondrial malate dehydrogenase (mMDH) activity is finely controlled in response to variations in mitochondrial adenine nucleotide balance.
      Title: Adenine nucleotide-dependent and redox-independent control of mitochondrial malate dehydrogenase activity in Arabidopsis thaliana.
    3. a metabolic repair cycle involving mMDH and l-2HGDH is conserved in plant and mammalian mitochondria. [Malate dehydrogenase] [mMDH1]
      Title: Plants Possess a Cyclic Mitochondrial Metabolic Pathway similar to the Mammalian Metabolic Repair Mechanism Involving Malate Dehydrogenase and l-2-Hydroxyglutarate Dehydrogenase.
    4. Mitochondrial malate dehydrogenase 1 exhibited a negative correlation of mRNA and protein levels during cold-acclimation and de-acclimation in Arabidopsis.
      Title: Analysis of differential expression patterns of mRNA and protein during cold-acclimation and de-acclimation in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_104202.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-malate dehydrogenase (NAD+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables copper ion binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in malate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in plant-type cell wall HDA PubMed 

    General protein information

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    Preferred Names
    Lactate/malate dehydrogenase family protein
    NP_564625.1
    • Lactate/malate dehydrogenase family protein; FUNCTIONS IN: malate dehydrogenase activity, copper ion binding; INVOLVED IN: response to cadmium ion, response to salt stress, response to cold, defense response to bacterium, peptidyl-cysteine S-nitrosylation; LOCATED IN: mitochondrion, cell wall, chloroplast; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Lactate/malate dehydrogenase, C-terminal (InterPro:IPR022383), Malate dehydrogenase, NAD-dependent, eukaryote/gamma proteobacteria (InterPro:IPR010097), NAD(P)-binding domain (InterPro:IPR016040), L-lactate/malate dehydrogenase (InterPro:IPR001557), Lactate/malate dehydrogenase, N-terminal (InterPro:IPR001236), Malate dehydrogenase, active site (InterPro:IPR001252), Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (InterPro:IPR015955); BEST Arabidopsis thaliana protein match is: Lactate/malate dehydrogenase family protein (TAIR:AT3G15020.1); Has 17502 Blast hits to 17499 proteins in 5422 species: Archae - 240; Bacteria - 12205; Metazoa - 1281; Fungi - 536; Plants - 649; Viruses - 0; Other Eukaryotes - 2591 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19854615..19857146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104202.3 → NP_564625.1  Lactate/malate dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564625.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LBB9, Q9MAH7, Q9ZP06
      UniProtKB/TrEMBL
      A0A178WFE8, A0A654EJR6
      Conserved Domains (2) summary
      cd01337
      Location:31 → 339
      MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases
      PLN00106
      Location:12 → 334
      PLN00106; malate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZP06.1

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