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    MYB65 myb domain protein 65 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820317, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MYB65
    Official Full Name
    myb domain protein 65
    Primary source
    TAIR:AT3G11440
    Locus tag
    AT3G11440
    See related
    Araport:AT3G11440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMYB65; myb domain protein 65; MYB DOMAIN PROTEIN 65
    Summary
    Member of the R2R3-MYB gene family. Similar to GA-induced Barley myb gene. May be induced during germination in response to GA. Double mutants with MYB33 are male sterile, showing defects in pollen development and anther development. Contains a binding site for miRNA159 and may be spatially regulated by this micro RNA. The male sterile phenotype of the MYB33/MYB65 double mutant is light and temperature sensitive. Fertility can be restored with increased light intensity and lower temperatures.
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    Genomic context

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    See MYB65 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (3602036..3605172)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene glycerol-3-phosphate acyltransferase 5 Neighboring gene ncRNA Neighboring gene DnaJ and Myb-like DNA-binding domain-containing protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene 4'-phosphopantetheinyl transferase superfamily

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis GAMYB-like genes, MYB33 and MYB65, are microRNA-regulated genes that redundantly facilitate anther development. Millar AA, et al. Plant Cell, 2005 Mar. PMID 15722475, Free PMC Article
    2. MicroRNAs with analogous target complementarities perform with highly variable efficacies in Arabidopsis. Deveson I, et al. FEBS Lett, 2013 Nov 15. PMID 24103298
    3. The microRNA159-regulated GAMYB-like genes inhibit growth and promote programmed cell death in Arabidopsis. Alonso-Peral MM, et al. Plant Physiol, 2010 Oct. PMID 20699403, Free PMC Article
    4. GAMYB-like genes, flowering, and gibberellin signaling in Arabidopsis. Gocal GF, et al. Plant Physiol, 2001 Dec. PMID 11743113, Free PMC Article
    5. Primary root growth in Arabidopsis thaliana is inhibited by the miR159 mediated repression of MYB33, MYB65 and MYB101. Xue T, et al. Plant Sci, 2017 Sep. PMID 28716415

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Primary root growth in Arabidopsis thaliana is inhibited by the miR159 mediated repression of MYB33, MYB65 and MYB101
      Title: Primary root growth in Arabidopsis thaliana is inhibited by the miR159 mediated repression of MYB33, MYB65 and MYB101.
    2. MiR159a and miR159b appear to continuously repress MYB33 and MYB65 expression to levels that have no major impact on rosette development.
      Title: Ubiquitous miR159 repression of MYB33/65 in Arabidopsis rosettes is robust and is not perturbed by a wide range of stresses.
    3. There may be factors, in addition to complementarity, that control plant miRNA efficacy, such factors appear to be optimised in regards to the endogenous and ancient miR159:MYB33/65 relationship.
      Title: MicroRNAs with analogous target complementarities perform with highly variable efficacies in Arabidopsis.
    4. MYB33 and MYB65 play no part in gibberellin-mediated growth or flowering in vegetative tissues.
      Title: The microRNA159-regulated GAMYB-like genes inhibit growth and promote programmed cell death in Arabidopsis.
    5. Consistent with functional redundancy, promoter-GUS fusions of MYB33 and MYB65 gave identical expression patterns in flowers (sepals, style, receptacle, anther filaments, and connective but not in anthers themselves), shoot apices, and root tips.
      Title: The Arabidopsis GAMYB-like genes, MYB33 and MYB65, are microRNA-regulated genes that redundantly facilitate anther development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001337926.1
    NM_001337927.1
    NM_111977.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anther development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anther wall tapetum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gibberellic acid mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen sperm cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein storage vacuole organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myb domain protein 65
    NP_187751.1
    • myb domain protein 65 (MYB65); CONTAINS InterPro DOMAIN/s: Transcription factor, GAMYB (InterPro:IPR016310), SANT, DNA-binding (InterPro:IPR001005), Myb, DNA-binding (InterPro:IPR014778), Homeodomain-like (InterPro:IPR009057), Myb transcription factor (InterPro:IPR015495), Homeodomain-related (InterPro:IPR012287), HTH transcriptional regulator, Myb-type, DNA-binding (InterPro:IPR017930); BEST Arabidopsis thaliana protein match is: myb domain protein 33 (TAIR:AT5G06100.3); Has 8961 Blast hits to 8327 proteins in 478 species: Archae - 0; Bacteria - 0; Metazoa - 727; Fungi - 480; Plants - 5988; Viruses - 3; Other Eukaryotes - 1763 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3602036..3605172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001337925.1 → NP_001327043.1  myb domain protein 65 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LR38, A0A5S9XB27, A0A654F7U0

    2. NM_111977.5 → NP_187751.1  myb domain protein 65 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187751.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65898, Q7DLH4, Q9FR97
      UniProtKB/TrEMBL
      A0A178VKX5, A0A7G2EP64
      Conserved Domains (1) summary
      PLN03091
      Location:41 → 146
      PLN03091; hypothetical protein; Provisional

    3. NM_001337926.1 → NP_001327044.1  myb domain protein 65 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65898, Q7DLH4, Q9FR97
      UniProtKB/TrEMBL
      A0A178VKX5, A0A7G2EP64
      Conserved Domains (1) summary
      PLN03091
      Location:41 → 146
      PLN03091; hypothetical protein; Provisional

    4. NM_001337927.1 → NP_001327042.1  myb domain protein 65 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65898, Q7DLH4, Q9FR97
      UniProtKB/TrEMBL
      A0A178VKX5, A0A7G2EP64
      Conserved Domains (1) summary
      PLN03091
      Location:41 → 146
      PLN03091; hypothetical protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FR97.1

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