U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GRF5 growth-regulating factor 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820609, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GRF5
    Official Full Name
    growth-regulating factor 5
    Primary source
    TAIR:AT3G13960
    Locus tag
    AT3G13960
    See related
    Araport:AT3G13960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtGRF5; growth-regulating factor 5
    Summary
    Growth regulating factor encoding transcription activator. One of the nine members of a GRF gene family, containing nuclear targeting domain. Involved in leaf development and expressed in root, shoot and flower.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GRF5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (4608076..4610497)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Dihydrolipoamide acetyltransferase, long form protein Neighboring gene DNA binding / DNA-directed RNA polymerase Neighboring gene ankyrin Neighboring gene miscRNA Neighboring gene Ubiquitin-like superfamily protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. GROWTH-REGULATING FACTORS Interact with DELLAs and Regulate Growth in Cold Stress. Lantzouni O, et al. Plant Cell, 2020 Apr. PMID 32060178, Free PMC Article
    2. The transcription factor AtGRF5 and the transcription coactivator AN3 regulate cell proliferation in leaf primordia of Arabidopsis thaliana. Horiguchi G, et al. Plant J, 2005 Jul. PMID 15960617
    3. Increased leaf size: different means to an end. Gonzalez N, et al. Plant Physiol, 2010 Jul. PMID 20460583, Free PMC Article
    4. The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis. Kim JH, et al. Plant J, 2003 Oct. PMID 12974814
    5. Molecular mechanism of microRNA396 mediating pistil development in Arabidopsis. Liang G, et al. Plant Physiol, 2014 Jan. PMID 24285851, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AN3 and AtGRF5 act together and are required for the development of appropriate leaf size and shape through the promotion and/or maintenance of cell proliferation. [AtGRF5]
      Title: The transcription factor AtGRF5 and the transcription coactivator AN3 regulate cell proliferation in leaf primordia of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_112250.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within leaf development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to gibberellin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to gibberellin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    growth-regulating factor 5
    NP_188012.2
    • growth-regulating factor 5 (GRF5); CONTAINS InterPro DOMAIN/s: Glutamine-Leucine-Glutamine, QLQ (InterPro:IPR014978), WRC (InterPro:IPR014977); BEST Arabidopsis thaliana protein match is: growth-regulating factor 2 (TAIR:AT4G37740.1); Has 2351 Blast hits to 1483 proteins in 168 species: Archae - 0; Bacteria - 108; Metazoa - 567; Fungi - 216; Plants - 548; Viruses - 4; Other Eukaryotes - 908 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4608076..4610497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112250.3 → NP_188012.2  growth-regulating factor 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188012.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0SVA9, Q8L8A6, Q9LVK4
      UniProtKB/TrEMBL
      A0A178VFH5, A0A178VGS1
      Conserved Domains (2) summary
      pfam08879
      Location:82 → 122
      WRC
      pfam08880
      Location:16 → 50
      QLQ
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L8A6.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools