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    ALF5 MATE efflux family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821935, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALF5
    Official Full Name
    MATE efflux family protein
    Primary source
    TAIR:AT3G23560
    Locus tag
    AT3G23560
    See related
    Araport:AT3G23560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ABERRANT LATERAL ROOT FORMATION 5
    Summary
    Member of the multidrug and toxic compound extrusion (MATE) family, protects roots from inhibitory compounds.
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    Genomic context

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    See ALF5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (8453903..8456708, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Cyclopropane-fatty-acyl-phospholipid synthase Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene MATE efflux family protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ribonucleotide reductase 2A Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis ALF5, a multidrug efflux transporter gene family member, confers resistance to toxins. Diener AC, et al. Plant Cell, 2001 Jul. PMID 11449055, Free PMC Article
    2. Uncovering Arabidopsis membrane protein interactome enriched in transporters using mating-based split ubiquitin assays and classification models. Chen J, et al. Front Plant Sci, 2012. PMID 22737156, Free PMC Article
    3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001338646.1
    NM_113259.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xenobiotic transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to toxic substance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MATE efflux family protein
    NP_566730.1
    • ABERRANT LATERAL ROOT FORMATION 5 (ALF5); FUNCTIONS IN: antiporter activity, drug transmembrane transporter activity, transporter activity; INVOLVED IN: response to toxin; LOCATED IN: membrane; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Multi antimicrobial extrusion protein MatE (InterPro:IPR002528); BEST Arabidopsis thaliana protein match is: MATE efflux family protein (TAIR:AT3G23550.1); Has 11709 Blast hits to 11651 proteins in 2060 species: Archae - 284; Bacteria - 8224; Metazoa - 146; Fungi - 324; Plants - 1351; Viruses - 0; Other Eukaryotes - 1380 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8453903..8456708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113259.4 → NP_566730.1  MATE efflux family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566730.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LUH2
      UniProtKB/TrEMBL
      A0A5S9XF04
      Conserved Domains (2) summary
      COG0534
      Location:46 → 475
      NorM; Na+-driven multidrug efflux pump [Defense mechanisms]
      cd13132
      Location:39 → 471
      MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

    2. NM_001338646.1 → NP_001327615.1  MATE efflux family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LSV7, A0A5S9XF04
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LUH2.1

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