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    ROF1 rotamase FKBP 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822117, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ROF1
    Official Full Name
    rotamase FKBP 1
    Primary source
    TAIR:AT3G25230
    Locus tag
    AT3G25230
    See related
    Araport:AT3G25230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFKBP62; FK506 BINDING PROTEIN 62; FKBP62; rotamase FKBP 1
    Summary
    Encodes a a high molecular weight member of the FK506 binding protein (FKBP) family. It has three FKBP12-like domains, tetratricopeptide repeats, and a putative calmodulin binding domain. Modulates thermotolerance by interacting with HSP90.1 and affecting the accumulation of HsfA2-regulated sHSPs. Belongs to one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808) with potential to interact with Hsp90/Hsp70 as co-chaperones.
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    Genomic context

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    See ROF1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Sequence:
    Chromosome: 3; NC_003074.8 (9188096..9191630)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene miscRNA Neighboring gene sulfate/thiosulfate import ATP-binding protein, putative (DUF506) Neighboring gene AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis thaliana immunophilin ROF1 directly interacts with PI(3)P and PI(3,5)P2 and affects germination under osmotic stress. Karali D, et al. PLoS One, 2012. PMID 23133621, Free PMC Article
    2. Novel structure of a high molecular weight FK506 binding protein from Arabidopsis thaliana. Vucich VA, et al. Mol Gen Genet, 1996 Oct 16. PMID 8914512
    3. Involvement of Arabidopsis ROF2 (FKBP65) in thermotolerance. Meiri D, et al. Plant Mol Biol, 2010 Jan. PMID 19876748
    4. Dynamics of mRNA fate during light stress and recovery: from transcription to stability and translation. Smith AB, et al. Plant J, 2024 Feb. PMID 37947266, Free PMC Article
    5. Selective autophagy regulates heat stress memory in Arabidopsis by NBR1-mediated targeting of HSP90.1 and ROF1. Thirumalaikumar VP, et al. Autophagy, 2021 Sep. PMID 32967551, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Selective autophagy regulates heat stress memory in Arabidopsis by NBR1-mediated targeting of HSP90.1 and ROF1.
      Title: Selective autophagy regulates heat stress memory in Arabidopsis by NBR1-mediated targeting of HSP90.1 and ROF1.
    2. ROF1 plays an important role in the osmotic/salt stress responses of germinating Arabidopsis thaliana seedlings
      Title: The Arabidopsis thaliana immunophilin ROF1 directly interacts with PI(3)P and PI(3,5)P2 and affects germination under osmotic stress.
    3. ROF1 prolongs thermotolerance by sustaining the levels of small HSPs that are essential for survival at high temperatures.
      Title: Arabidopsis ROF1 (FKBP62) modulates thermotolerance by interacting with HSP90.1 and affecting the accumulation of HsfA2-regulated sHSPs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001125223.1
    NM_113429.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to high light intensity IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    rotamase FKBP 1
    NP_001118695.1
    • rotamase FKBP 1 (ROF1); CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: FKBP-type peptidyl-prolyl cis-trans isomerase family protein (TAIR:AT5G48570.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_189160.3
    • rotamase FKBP 1 (ROF1); FUNCTIONS IN: FK506 binding, peptidyl-prolyl cis-trans isomerase activity, calmodulin binding; INVOLVED IN: response to cadmium ion, response to heat, response to wounding; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734), Peptidyl-prolyl cis-trans isomerase, FKBP-type (InterPro:IPR001179); BEST Arabidopsis thaliana protein match is: FKBP-type peptidyl-prolyl cis-trans isomerase family protein (TAIR:AT5G48570.1); Has 23486 Blast hits to 15115 proteins in 1840 species: Archae - 212; Bacteria - 9362; Metazoa - 6200; Fungi - 1716; Plants - 1995; Viruses - 0; Other Eukaryotes - 4001 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      9188096..9191630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113429.5 → NP_189160.3  rotamase FKBP 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189160.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38931, Q38949, Q9LSF3
      UniProtKB/TrEMBL
      A0A178VH19, A0A5S9XH24
      Conserved Domains (4) summary
      COG1047
      Location:174 → 234
      SlpA; FKBP-type peptidyl-prolyl cis-trans isomerase 2 [Posttranslational modification, protein turnover, chaperones]
      TIGR00990
      Location:357 → 537
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:400 → 438
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:50 → 142
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase

    2. NM_001125223.1 → NP_001118695.1  rotamase FKBP 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118695.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FAH8, B3H746
      Conserved Domains (4) summary
      sd00006
      Location:400 → 438
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:50 → 142
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam00515
      Location:483 → 516
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:443 → 514
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38931.2

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