MOS2 D111/G-patch domain-containing protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MOS2
Official Full Name: D111/G-patch domain-containing protein
Primary source: TAIR:AT1G33520
Locus tag: AT1G33520
See related: Araport:AT1G33520
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 2; F10C21.16; F10C21_16; modifier of snc1
Summary: Has single homolog in Arabidopsis, also homologs in human, mouse and C. elegans; contains one G-patch domain (known to mediate RNA-protein interactions) and two KOW domains (may bind RNA and/or protein); localized to the nucleus; mutant suppresses high SA levels and constitutive disease resistance in snc1 npr1 background; required for basal resistance against Pseudomonas syringae maculicola ES4326 and R gene-mediated resistance specified by RPM1, PPS4 and RPP4
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Genomic context

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See MOS2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 1

Sequence:: Chromosome: 1; NC_003070.9 (12157054..12159125, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MOS2 contributes to proper splicing of SNC1 transcript, redundantly with MOS2H.
Title: MOS2 has redundant function with its homolog MOS2H and is required for proper splicing of SNC1.
MOS2 promotes pri-miRNA processing through facilitating the recruitment of pri-miRNAs by the Dicing complexes.
Title: A role for the RNA-binding protein MOS2 in microRNA maturation in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_103076.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innate immune response-activating signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: D111/G-patch domain-containing protein

NP_174617.1

modifier of snc1, 2 (MOS2); CONTAINS InterPro DOMAIN/s: D111/G-patch (InterPro:IPR000467), KOW (InterPro:IPR005824); BEST Arabidopsis thaliana protein match is: D111/G-patch domain-containing protein (TAIR:AT4G25020.1); Has 453 Blast hits to 441 proteins in 156 species: Archae - 0; Bacteria - 0; Metazoa - 209; Fungi - 80; Plants - 100; Viruses - 0; Other Eukaryotes - 64 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

12157054..12159125 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_103076.4 → NP_174617.1 D111/G-patch domain-containing protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_174617.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9C801

UniProtKB/TrEMBL

A0A5S9WL97, A0A654EEY8

Conserved Domains (2) summary

cd13153
Location:405 → 455

KOW_GPKOW_B; KOW motif of the "G-patch domain and KOW motifs-containing protein" (GPKOW) repeat B

pfam12656
Location:143 → 202

G-patch_2; G-patch domain