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    MLH1 MUTL-homologue 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826493, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MLH1
    Official Full Name
    MUTL-homologue 1
    Primary source
    TAIR:AT4G09140
    Locus tag
    AT4G09140
    See related
    Araport:AT4G09140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA MUTL-HOMOLOGUE 1; ATMLH1; F23J3.170; F23J3_170; MUTL-homologue 1
    Summary
    Encodes a protein with similarity to Mut1 DNA mismatch repair protein, from E.coli. The protein is expressed during prophase I of meiosis, colocalizes with MLH3 throughout pachytene and is dependent on MLH3 for proper localization.
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    Genomic context

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    See MLH1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    16
    Sequence:
    Chromosome: 4; NC_003075.7 (5816942..5821066, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene RING/U-box superfamily protein Neighboring gene miscRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Arabidopsis MLH1 mutant exhibits reproductive defects and reveals a dual role for this gene in mitotic recombination. Dion E, et al. Plant J, 2007 Aug. PMID 17559505
    2. Isolation and characterization of AtMLH1, a MutL homologue from Arabidopsis thaliana. Jean M, et al. Mol Gen Genet, 1999 Dec. PMID 10628846
    3. Replication protein A (AtRPA1a) is required for class I crossover formation but is dispensable for meiotic DNA break repair. Osman K, et al. EMBO J, 2009 Feb 18. PMID 19153602, Free PMC Article
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. required for recombination and acts to limit recombination between diverged sequences
      Title: An Arabidopsis MLH1 mutant exhibits reproductive defects and reveals a dual role for this gene in mitotic recombination.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_001340612.1
    NM_116983.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fruit development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mismatch repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mismatch repair complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MUTL-homologue 1
    NP_567345.2
    • MUTL-homologue 1 (MLH1); FUNCTIONS IN: protein binding, bridging; INVOLVED IN: in 6 processes; LOCATED IN: nuclear chromatin; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein Mlh1 (InterPro:IPR011186), DNA mismatch repair, conserved site (InterPro:IPR014762), ATPase-like, ATP-binding domain (InterPro:IPR003594), DNA mismatch repair protein, C-terminal (InterPro:IPR013507), DNA mismatch repair protein, N-terminal (InterPro:IPR014763), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), DNA mismatch repair protein (InterPro:IPR002099), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721); BEST Arabidopsis thaliana protein match is: DNA mismatch repair protein, putative (TAIR:AT4G02460.1); Has 6802 Blast hits to 6727 proteins in 2342 species: Archae - 68; Bacteria - 4480; Metazoa - 469; Fungi - 496; Plants - 114; Viruses - 0; Other Eukaryotes - 1175 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      5816942..5821066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116983.3 → NP_567345.2  MUTL-homologue 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567345.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5F9, Q9ZRV4
      UniProtKB/TrEMBL
      A0A654FML5
      Conserved Domains (4) summary
      cd03483
      Location:232 → 358
      MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
      TIGR00585
      Location:28 → 338
      mutl; DNA mismatch repair protein MutL
      pfam16413
      Location:453 → 737
      Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
      cl00075
      Location:49 → 159
      HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

    2. NM_001340612.1 → NP_001328542.1  MUTL-homologue 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B4Y5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZRV4.1

    Gene LinkOut

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