CHX17 cation/H+ exchanger 17 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CHX17
Official Full Name: cation/H+ exchanger 17
Primary source: TAIR:AT4G23700
Locus tag: AT4G23700
See related: Araport:AT4G23700
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATCHX17; cation/H+ exchanger 17; F9D16.170; F9D16_170
Summary: member of Putative Na+/H+ antiporter family
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Genomic context

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See CHX17 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 4

Sequence:: Chromosome: 4; NC_003075.7 (12342376..12346051, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fertility could be partially compromised by impaired pollen tube and/or sperm function as CHX19 and CHX18 are expressed in the pollen tube and sperm cell, respectively. CHX17 and CHX18 proteins may promote embryo development possibly through the endosperm where these genes are expressed.
Title: Transporters involved in pH and K+ homeostasis affect pollen wall formation, male fertility, and embryo development.
The core of AtCHX17 models according to EcNhaA and TtNapA templates faces inward and outward, respectively, which may reflect two conformational states of the alternating access transport mode for proteins belonging to the plant CHX family
Title: Protein architecture and core residues in unwound α-helices provide insights to the transport function of plant AtCHX17.
successful reproduction and seed development depend on the ability to regulate cation and pH homeostasis by AtCHX17-like transporters on membranes that traffic in the endocytic and/or secretory pathways
Title: K+ transporter AtCHX17 with its hydrophilic C tail localizes to membranes of the secretory/endocytic system: role in reproduction and seed set.
Plant-specific cation/H+ exchanger 17 and its homologs are endomembrane K+ transporters with roles in protein sorting.
Title: Plant-specific cation/H+ exchanger 17 and its homologs are endomembrane K+ transporters with roles in protein sorting.
AtCHX17 was expressed preferentially in epidermal and cortical cells of the mature root zones.
Title: Characterization of AtCHX17, a member of the cation/H+ exchangers, CHX family, from Arabidopsis thaliana suggests a role in K+ homeostasis.
results show that the proteins Arabidopsis thaliana Chx17 and Saccharomyces cerevisiae Kha1 could have similar functions.
Title: Arabidopsis thaliana CHX17 gene complements the kha1 deletion phenotypes in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001341626.1

Supported by ESTs:

NM_118501.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables sodium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of pH	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: cation/H+ exchanger 17

NP_194101.1

cation/H+ exchanger 17 (CHX17); FUNCTIONS IN: monovalent cation:hydrogen antiporter activity, sodium:hydrogen antiporter activity; INVOLVED IN: N-terminal protein myristoylation, cation transport; LOCATED IN: integral to membrane; EXPRESSED IN: stem, sepal, root, leaf, stamen; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: Cation/H+ exchanger (InterPro:IPR006153); BEST Arabidopsis thaliana protein match is: cation/H+ exchanger 18 (TAIR:AT5G41610.1); Has 10581 Blast hits to 10541 proteins in 2184 species: Archae - 402; Bacteria - 8255; Metazoa - 59; Fungi - 207; Plants - 679; Viruses - 0; Other Eukaryotes - 979 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

12342376..12346051 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118501.5 → NP_194101.1 cation/H+ exchanger 17 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194101.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SUQ7

UniProtKB/TrEMBL

A0A178UUP6, A0A5S9XV70

Conserved Domains (3) summary

PLN03159
Location:2 → 800

PLN03159; cation/H(+) antiporter 15; Provisional

COG0475
Location:28 → 428

KefB; Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]

cl00292
Location:462 → 613

AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
NM_001341626.1 → NP_001328705.1 cation/H+ exchanger 17 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SUQ7

UniProtKB/TrEMBL

A0A178UUP6, A0A5S9XV70