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    TPI triosephosphate isomerase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824710, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TPI
    Official Full Name
    triosephosphate isomerase
    Primary source
    TAIR:AT3G55440
    Locus tag
    AT3G55440
    See related
    Araport:AT3G55440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCTIMC; CYTOSOLIC ISOFORM TRIOSE PHOSPHATE ISOMERASE; CYTOSOLIC TRIOSE PHOSPHATE ISOMERASE; CYTOTPI; triosephosphate isomerase; TRIOSEPHOSPHATE ISOMERASE
    Summary
    Encodes triosephosphate isomerase.
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    Genomic context

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    See TPI in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (20553403..20556560)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene O-Glycosyl hydrolases family 17 protein Neighboring gene PBS1-like 1 Neighboring gene SC35-like splicing factor 30

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sugar-metabolic enzymes aldolase and triose-phosphate isomerase are targets of glutathionylation in Arabidopsis thaliana: detection using biotinylated glutathione. Ito H, et al. Plant Cell Physiol, 2003 Jul. PMID 12881492
    2. The plastid isoform of triose phosphate isomerase is required for the postgerminative transition from heterotrophic to autotrophic growth in Arabidopsis. Chen M, et al. Plant Cell, 2010 Jan. PMID 20097871, Free PMC Article
    3. Enzymes of glycolysis are functionally associated with the mitochondrion in Arabidopsis cells. Giegé P, et al. Plant Cell, 2003 Sep. PMID 12953116, Free PMC Article
    4. Identification of zinc-responsive proteins in the roots of Arabidopsis thaliana using a highly improved method of two-dimensional electrophoresis. Fukao Y, et al. Plant Cell Physiol, 2009 Dec. PMID 19880396
    5. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduction of plastid TPI activity results in the buildup of glycerol, glycerol-3-phosphate, dihydroxyacetone phosphate, and methylglyoxal following seed germination.
      Title: The plastid isoform of triose phosphate isomerase is required for the postgerminative transition from heterotrophic to autotrophic growth in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115402.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding HDA PubMed 
    enables triose-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glycolytic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    triosephosphate isomerase
    NP_191104.1
    • triosephosphate isomerase (TPI); FUNCTIONS IN: triose-phosphate isomerase activity, copper ion binding; INVOLVED IN: in 7 processes; LOCATED IN: in 8 components; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Triosephosphate isomerase, active site (InterPro:IPR020861), Aldolase-type TIM barrel (InterPro:IPR013785), Triosephosphate isomerase (InterPro:IPR000652); BEST Arabidopsis thaliana protein match is: triosephosphate isomerase (TAIR:AT2G21170.1); Has 11466 Blast hits to 11464 proteins in 3595 species: Archae - 48; Bacteria - 6204; Metazoa - 1205; Fungi - 243; Plants - 477; Viruses - 0; Other Eukaryotes - 3289 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20553403..20556560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115402.4 → NP_191104.1  triosephosphate isomerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191104.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48491, Q9M2T5
      UniProtKB/TrEMBL
      A0A178VM57, A0A5S9XL15
      Conserved Domains (1) summary
      PLN02561
      Location:1 → 253
      PLN02561; triosephosphate isomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48491.2

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