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    ROC2 rotamase cyclophilin 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824773, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ROC2
    Official Full Name
    rotamase cyclophilin 2
    Primary source
    TAIR:AT3G56070
    Locus tag
    AT3G56070
    See related
    Araport:AT3G56070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    rotamase cyclophilin 2; ROTAMASE CYCLOPHILIN 2; ROTAMASE CYP 2
    Summary
    rotamase cyclophilin 2 (ROC2) exhibiting peptidyl-prolyl cis-trans isomerase activity involved in signal transduction.
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    Genomic context

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    See ROC2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (20806566..20808168, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Protein kinase family protein Neighboring gene Glucose-methanol-choline (GMC) oxidoreductase family protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Peptidyl-Prolyl Cis-Trans Isomerase- and Calmodulin-Binding Activity of a Cytosolic Arabidopsis thaliana Cyclophilin AtCyp19-3. Kaur G, et al. PLoS One, 2015. PMID 26317213, Free PMC Article
    2. Cyclophilin A binds to the viral RNA and replication proteins, resulting in inhibition of tombusviral replicase assembly. Kovalev N, et al. J Virol, 2013 Dec. PMID 24089553, Free PMC Article
    3. Characterization of the cyclophilin gene family of Arabidopsis thaliana and phylogenetic analysis of known cyclophilin proteins. Chou IT, et al. Plant Mol Biol, 1997 Dec. PMID 9426607
    4. Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays. Popescu SC, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360592, Free PMC Article
    5. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Roc1, and Roc2 binds to the Tomato bushy stunt tombusvirus RNA and replication proteins, resulting in inhibition of virus repication.
      Title: Cyclophilin A binds to the viral RNA and replication proteins, resulting in inhibition of tombusviral replicase assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001339763.1
    NM_115465.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cyclosporin A binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    rotamase cyclophilin 2
    NP_001319764.1
    • rotamase cyclophilin 2 (ROC2); CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (InterPro:IPR020892); BEST Arabidopsis thaliana protein match is: rotamase CYP 3 (TAIR:AT2G16600.1); Has 16518 Blast hits to 16486 proteins in 2631 species: Archae - 108; Bacteria - 6748; Metazoa - 2914; Fungi - 1377; Plants - 1262; Viruses - 4; Other Eukaryotes - 4105 (source: NCBI BLink).
    NP_191166.1
    • rotamase cyclophilin 2 (ROC2); FUNCTIONS IN: peptidyl-prolyl cis-trans isomerase activity, cyclosporin A binding; INVOLVED IN: protein folding, response to cadmium ion, signal transduction; LOCATED IN: cytosol; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclophilin-like (InterPro:IPR015891), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (InterPro:IPR002130), Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, conserved site (InterPro:IPR020892); BEST Arabidopsis thaliana protein match is: rotamase CYP 3 (TAIR:AT2G16600.1); Has 16518 Blast hits to 16486 proteins in 2631 species: Archae - 108; Bacteria - 6748; Metazoa - 2914; Fungi - 1377; Plants - 1262; Viruses - 4; Other Eukaryotes - 4105 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20806566..20808168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115465.5 → NP_191166.1  rotamase cyclophilin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191166.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38867, Q38901, Q9LYN4
      UniProtKB/TrEMBL
      A0A178VE97, A0A5S9XL84
      Conserved Domains (1) summary
      cd01926
      Location:4 → 169
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

    2. NM_001339763.1 → NP_001319764.1  rotamase cyclophilin 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38867, Q38901, Q9LYN4
      UniProtKB/TrEMBL
      A0A178VE97, A0A5S9XL84
      Conserved Domains (1) summary
      cd01926
      Location:4 → 169
      cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38867.2

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