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    CBL cystathionine beta-lyase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824872, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CBL
    Official Full Name
    cystathionine beta-lyase
    Primary source
    TAIR:AT3G57050
    Locus tag
    AT3G57050
    See related
    Araport:AT3G57050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cystathionine beta-lyase
    Summary
    Encodes second enzyme in the methionine biosynthetic pathway
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    Genomic context

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    See CBL in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Sequence:
    Chromosome: 3; NC_003074.8 (21111700..21114737, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene response regulator 9 Neighboring gene binding protein Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cystathionine beta-lyase is crucial for embryo patterning and the maintenance of root stem cell niche in Arabidopsis. Liu G, et al. Plant J, 2019 Aug. PMID 31002461
    2. Cloning of an Arabidopsis thaliana cDNA encoding cystathionine beta-lyase by functional complementation in Escherichia coli. Ravanel S, et al. Plant Mol Biol, 1995 Nov. PMID 8541513
    3. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article
    4. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article
    5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that cystathionine beta-lyase (cbl) mutant has impaired embryo patterning, defective root stem cell niche and stunted root growth.
      Title: Cystathionine beta-lyase is crucial for embryo patterning and the maintenance of root stem cell niche in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001339838.1
    NM_001339839.1
    NM_115564.4
    NM_180381.3
    NM_180382.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-S-conjugate beta-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-S-conjugate beta-lyase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' L-methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-methionine biosynthetic process from L-homoserine via cystathionine TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in transsulfuration IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cystathionine beta-lyase
    NP_191264.1
    • cystathionine beta-lyase (CBL); FUNCTIONS IN: cystathionine beta-lyase activity; INVOLVED IN: L-methionine biosynthetic process from L-homoserine via cystathionine; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Cystathionine beta-lyase, eukaryotic (InterPro:IPR006238), Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (InterPro:IPR000277), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT3G01120.1); Has 21174 Blast hits to 21168 proteins in 2454 species: Archae - 221; Bacteria - 12373; Metazoa - 223; Fungi - 823; Plants - 274; Viruses - 1; Other Eukaryotes - 7259 (source: NCBI BLink).
    NP_850712.1
    • cystathionine beta-lyase (CBL); FUNCTIONS IN: cystathionine beta-lyase activity; INVOLVED IN: L-methionine biosynthetic process from L-homoserine via cystathionine; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (InterPro:IPR000277), Cystathionine beta-lyase, eukaryotic (InterPro:IPR006238), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT3G01120.1); Has 21173 Blast hits to 21167 proteins in 2454 species: Archae - 221; Bacteria - 12375; Metazoa - 223; Fungi - 823; Plants - 274; Viruses - 1; Other Eukaryotes - 7256 (source: NCBI BLink).
    NP_850713.1
    • cystathionine beta-lyase (CBL); FUNCTIONS IN: cystathionine beta-lyase activity; INVOLVED IN: L-methionine biosynthetic process from L-homoserine via cystathionine; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Cys/Met metabolism, pyridoxal phosphate-dependent enzyme (InterPro:IPR000277), Cystathionine beta-lyase, eukaryotic (InterPro:IPR006238), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: Pyridoxal phosphate (PLP)-dependent transferases superfamily protein (TAIR:AT3G01120.1); Has 20092 Blast hits to 20089 proteins in 2449 species: Archae - 218; Bacteria - 12272; Metazoa - 204; Fungi - 782; Plants - 267; Viruses - 1; Other Eukaryotes - 6348 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21111700..21114737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180381.3 → NP_850712.1  cystathionine beta-lyase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FH56
      Conserved Domains (1) summary
      PLN02509
      Location:1 → 449
      PLN02509; cystathionine beta-lyase

    2. NM_115564.4 → NP_191264.1  cystathionine beta-lyase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191264.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53780, Q8VZL8
      UniProtKB/TrEMBL
      A0A5S9XLM1, A0A654FH56, B9DGA0
      Conserved Domains (1) summary
      PLN02509
      Location:1 → 464
      PLN02509; cystathionine beta-lyase

    3. NM_180382.1 → NP_850713.1  cystathionine beta-lyase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850713.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FH56, F4J244
      Conserved Domains (1) summary
      cl18945
      Location:1 → 372
      AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

    4. NM_001339838.1 → NP_001326867.1  cystathionine beta-lyase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQK6, A0A654FH56

    5. NM_001339839.1 → NP_001326868.1  cystathionine beta-lyase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQK7, A0A654FH56
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53780.1

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