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    KAC1 kinesin like protein for actin based chloroplast movement 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830911, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KAC1
    Official Full Name
    kinesin like protein for actin based chloroplast movement 1
    Primary source
    TAIR:AT5G10470
    Locus tag
    AT5G10470
    See related
    Araport:AT5G10470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F12B17.180; F12B17_180; KCA1; KINESIN CDKA;1 ASSOCIATED 1; kinesin like protein for actin based chloroplast movement 1
    Summary
    Kinesin that binds cyclin-dependent kinase CDKA;1 as homodimer or as heterodimer with KCA2. Demarcates the division site in plant cells.
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    Genomic context

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    See KAC1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    23
    Sequence:
    Chromosome: 5; NC_003076.8 (3289925..3297434, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene G-box regulating factor 6 Neighboring gene tRNA-Ser Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene Protein-tyrosine phosphatase-like, PTPLA Neighboring gene MSCS-like 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell cycle-dependent targeting of a kinesin at the plasma membrane demarcates the division site in plant cells. Vanstraelen M, et al. Curr Biol, 2006 Feb 7. PMID 16461285
    2. Comprehensive comparative analysis of kinesins in photosynthetic eukaryotes. Richardson DN, et al. BMC Genomics, 2006 Jan 31. PMID 16448571, Free PMC Article
    3. Two kinesin-like proteins mediate actin-based chloroplast movement in Arabidopsis thaliana. Suetsugu N, et al. Proc Natl Acad Sci U S A, 2010 May 11. PMID 20418504, Free PMC Article
    4. Light-Induced Movements of Chloroplasts and Nuclei Are Regulated in Both Cp-Actin-Filament-Dependent and -Independent Manners in Arabidopsis thaliana. Suetsugu N, et al. PLoS One, 2016. PMID 27310016, Free PMC Article
    5. A plant-specific subclass of C-terminal kinesins contains a conserved a-type cyclin-dependent kinase site implicated in folding and dimerization. Vanstraelen M, et al. Plant Physiol, 2004 Jul. PMID 15247388, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results indicate that CHUP1 and KAC1/KAC2 function somewhat independently, but interdependently mediate both chloroplast and nuclear photorelocation movements in Arabidopsis cells.
      Title: Light-Induced Movements of Chloroplasts and Nuclei Are Regulated in Both Cp-Actin-Filament-Dependent and -Independent Manners in Arabidopsis thaliana.
    2. Two kinesin-like proteins, KAC1 and KAC2, are essential for chloroplast to move via cp-actin filaments and anchor to the plasma membrane. [KAC1]
      Title: Two kinesin-like proteins mediate actin-based chloroplast movement in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001085096.1
    NM_121085.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within chloroplast accumulation movement IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chloroplast accumulation movement IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within chloroplast avoidance movement IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chloroplast avoidance movement IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within cytokinesis by cell plate formation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear migration along microfilament IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within preprophase band assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell plate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular anatomical structure IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in phragmoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin like protein for actin based chloroplast movement 1
    NP_001078565.1
    • kinesin like protein for actin based chloroplast movement 1 (KAC1); FUNCTIONS IN: microtubule binding, protein binding, microtubule motor activity; INVOLVED IN: preprophase band assembly, chloroplast avoidance movement, chloroplast accumulation movement, cytokinesis; LOCATED IN: cytosol, plasma membrane, membrane, cell plate, phragmoplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: kinesin like protein for actin based chloroplast movement 2 (TAIR:AT5G65460.1); Has 13820 Blast hits to 12778 proteins in 615 species: Archae - 30; Bacteria - 578; Metazoa - 6060; Fungi - 1488; Plants - 1898; Viruses - 6; Other Eukaryotes - 3760 (source: NCBI BLink).
    NP_196609.1
    • kinesin like protein for actin based chloroplast movement 1 (KAC1); FUNCTIONS IN: microtubule binding, protein binding, microtubule motor activity; INVOLVED IN: preprophase band assembly, chloroplast avoidance movement, chloroplast accumulation movement, cytokinesis; LOCATED IN: in 6 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Kinesin, motor region, conserved site (InterPro:IPR019821), Kinesin, motor domain (InterPro:IPR001752); BEST Arabidopsis thaliana protein match is: kinesin like protein for actin based chloroplast movement 2 (TAIR:AT5G65460.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3289925..3297434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001085096.1 → NP_001078565.1  kinesin like protein for actin based chloroplast movement 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y3B2
      Conserved Domains (2) summary
      cl22853
      Location:140 → 457
      Motor_domain; Myosin and Kinesin motor domain
      pfam00225
      Location:148 → 456
      Kinesin; Kinesin motor domain

    2. NM_121085.3 → NP_196609.1  kinesin like protein for actin based chloroplast movement 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196609.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H459, O23652, Q0WVP0, Q9LX99
      UniProtKB/TrEMBL
      A0A5S9Y3B2
      Conserved Domains (2) summary
      cl22853
      Location:140 → 457
      Motor_domain; Myosin and Kinesin motor domain
      pfam00225
      Location:148 → 456
      Kinesin; Kinesin motor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LX99.1

    Gene LinkOut

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