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    KAPP kinase associated protein phosphatase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832048, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KAPP
    Official Full Name
    kinase associated protein phosphatase
    Primary source
    TAIR:AT5G19280
    Locus tag
    AT5G19280
    See related
    Araport:AT5G19280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    kinase associated protein phosphatase; RAG1; ROOT ATTENUATED GROWTH 1; T24G5.3
    Summary
    kinase associated protein phosphatase composed of three domains: an amino-terminal signal anchor, a kinase interaction (KI) domain, and a type 2C protein phosphatase catalytic region
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    Genomic context

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    See KAPP in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    14
    Sequence:
    Chromosome: 5; NC_003076.8 (6488309..6493439)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene reverse transcriptase-like protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene methyltransferase C9orf114 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis kinase-associated protein phosphatase regulates adaptation to Na+ stress. Manabe Y, et al. Plant Physiol, 2008 Feb. PMID 18162596, Free PMC Article
    2. Interaction of a protein phosphatase with an Arabidopsis serine-threonine receptor kinase. Stone JM, et al. Science, 1994 Nov 4. PMID 7973632
    3. A possible role for kinase-associated protein phosphatase in the Arabidopsis CLAVATA1 signaling pathway. Williams RW, et al. Proc Natl Acad Sci U S A, 1997 Sep 16. PMID 9294234, Free PMC Article
    4. Identification of target ligands of CORYNE in Arabidopsis by phage display library. Zhao H, et al. J Integr Plant Biol, 2011 Apr. PMID 21214859
    5. Control of meristem development by CLAVATA1 receptor kinase and kinase-associated protein phosphatase interactions. Stone JM, et al. Plant Physiol, 1998 Aug. PMID 9701578, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a positive function of WAK1 and a negative function of GRP-3 and KAPP in the oligogalacturonides-triggered expression of defence genes and the production of an oxidative burst, is reported.
      Title: GRP-3 and KAPP, encoding interactors of WAK1, negatively affect defense responses induced by oligogalacturonides and local response to wounding.
    2. These results implicate KAPP as a functional component of the RLK signaling pathway, which also mediates adaptation to Na(+) stress.
      Title: The Arabidopsis kinase-associated protein phosphatase regulates adaptation to Na+ stress.
    3. The crystal structure of the binary complex of Ca-SOS3 with the C-terminal regulatory moiety of SOS2 resolves central questions regarding the dual function of SOS2 as a kinase and a phosphatase-binding protein.
      Title: The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3.
    4. Phosphopeptide binding introduces conformational fluctuations to residues of the long recognition loop of the kinase-interacting-forkhead-associated domain of KAPP; rigidity of this domain appears to couple as a whole to phosphothreonine peptide binding.
      Title: PhosphoThr peptide binding globally rigidifies much of the FHA domain from Arabidopsis receptor kinase-associated protein phosphatase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001161248.1
    NM_121933.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables [pyruvate kinase]-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of meristem structural organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinase associated protein phosphatase
    NP_001154720.1
    • kinase associated protein phosphatase (KAPP); CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C, manganese/magnesium aspartate binding site (InterPro:IPR000222), SMAD/FHA domain (InterPro:IPR008984), Protein phosphatase 2C-related (InterPro:IPR001932), Kinase associated protein phosphatase (InterPro:IPR016660), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045), Forkhead-associated (FHA) domain (InterPro:IPR000253); BEST Arabidopsis thaliana protein match is: HOPW1-1-interacting 2 (TAIR:AT4G31750.1); Has 4575 Blast hits to 4572 proteins in 441 species: Archae - 0; Bacteria - 429; Metazoa - 1040; Fungi - 314; Plants - 1891; Viruses - 3; Other Eukaryotes - 898 (source: NCBI BLink).
    NP_197429.1
    • kinase associated protein phosphatase (KAPP); CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C, manganese/magnesium aspartate binding site (InterPro:IPR000222), SMAD/FHA domain (InterPro:IPR008984), Protein phosphatase 2C-related (InterPro:IPR001932), Kinase associated protein phosphatase (InterPro:IPR016660), Protein phosphatase 2C, N-terminal (InterPro:IPR014045), Protein phosphatase 2C (InterPro:IPR015655), Forkhead-associated (FHA) domain (InterPro:IPR000253); BEST Arabidopsis thaliana protein match is: HOPW1-1-interacting 2 (TAIR:AT4G31750.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6488309..6493439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121933.4 → NP_197429.1  kinase associated protein phosphatase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197429.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P46014
      UniProtKB/TrEMBL
      A0A178URK7, A0A5S9Y7T7, A0A654G2E3
      Conserved Domains (2) summary
      cd00060
      Location:181 → 295
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00481
      Location:309 → 570
      PP2C; Protein phosphatase 2C

    2. NM_001161248.1 → NP_001154720.1  kinase associated protein phosphatase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154720.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178URK7, A0A5S9Y7T7, F4K124
      Conserved Domains (3) summary
      COG1716
      Location:211 → 296
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:181 → 295
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam00481
      Location:309 → 580
      PP2C; Protein phosphatase 2C
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46014.2

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