SOS3 Calcium-binding EF-hand family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SOS3
Official Full Name: Calcium-binding EF-hand family protein
Primary source: TAIR:AT5G24270
Locus tag: AT5G24270
See related: Araport:AT5G24270
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATSOS3; CALCINEURIN B-LIKE PROTEIN 4; CBL4; MOP9.19; MOP9_19; SALT OVERLY SENSITIVE 3
Summary: encodes a calcium sensor that is essential for K+ nutrition, K+/Na+ selectivity, and salt tolerance. The protein is similar to calcineurin B. Lines carrying recessive mutations are hypersensitive to Na+ and Li+ stresses and is unable to grow in low K+. The growth defect is rescued by extracellular calcium.
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Genomic context

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See SOS3 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 8

Sequence:: Chromosome: 5; NC_003076.8 (8238428..8243443, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural and molecular dynamics simulation studies of CBL-interacting protein kinase CIPK and its complexes related to plant salinity stress.
Title: Structural and molecular dynamics simulation studies of CBL-interacting protein kinase CIPK and its complexes related to plant salinity stress.
Interaction between CBL4 and CBL10 and found that the cbl4 cbl10 double mutant was dramatically more sensitive to salt as compared to the cbl4 and cbl10 single mutants, suggesting that CBL4 and CBL10 each directs a different salt-tolerance pathway.
Title: Calcineurin B-Like Proteins CBL4 and CBL10 Mediate Two Independent Salt Tolerance Pathways in Arabidopsis.
AtMyb73 expression was upregulated by salt stress but not by other stresses. Accumulation of salt overly sensitive (SOS) transcripts, SOS1 and SOS3, was higher in atmyb73 ko and atmyb73 eko plants than in wild type plants receiving 300mM NaCl treatment.
Title: Loss of the R2R3 MYB, AtMyb73, causes hyper-induction of the SOS1 and SOS3 genes in response to high salinity in Arabidopsis.
SOS3 mediated actin filament reorganization plays important roles in plant responses to salt stress.
Title: Arabidopsis SOS3 plays an important role in salt tolerance by mediating calcium-dependent microfilament reorganization.
The phosphate-accumulating mutants siz1 and pho2 reduce the uptake and accumulation of Na(+), leading to enhanced salt tolerance, and that, genetically, SIZ1 and PHO2 are likely independent of SOS3-dependent salt signaling.
Title: Increased tolerance to salt stress in the phosphate-accumulating Arabidopsis mutants siz1 and pho2.
CBL4 together with the interacting protein kinase CIPK6 modulates the activity and plasma membrane targeting of the K(+) channel AKT2.
Title: Calcium-dependent modulation and plasma membrane targeting of the AKT2 potassium channel by the CBL4/CIPK6 calcium sensor/protein kinase complex.
These data uncover a novel role of the SOS3 gene in modulation of lateral root developmental plasticity and adaptation in response to low salt stress.
Title: SOS3 mediates lateral root development under low salt stress through regulation of auxin redistribution and maxima in Arabidopsis.
CBL4 is the barley homologue of the Arabidopsis SOS3 controlling the Na+ transport.
Title: A SOS3 homologue maps to HvNax4, a barley locus controlling an environmentally sensitive Na+ exclusion trait.
SOS3 and AtHKT1 are major determinants of salinity resistance such that sos3 more strongly causes Na+ overaccumulation in roots, whereas athkt1 causes an increase in Na+ levels in the xylem sap and shoots and a concomitant Na+ reduction in roots.
Title: Calcium regulation of sodium hypersensitivities of sos3 and athkt1 mutants.
SOS2 family of protein kinases and their activators, the SOS3 family of calcium-binding proteins, function together; SOS2 is activated by Ca-SOS3 and subsequently phosphorylates ion transporter SOS1 to protect cellular ion homeostasis under salt stress
Title: The structure of the C-terminal domain of the protein kinase AtSOS2 bound to the calcium sensor AtSOS3.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001203448.2

Supported by ESTs:

NM_001343863.1

Supported by ESTs:

NM_122333.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables calcium-dependent protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hypotonic salinity response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular potassium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of calcineurin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Calcium-binding EF-hand family protein

NP_001190377.1

SALT OVERLY SENSITIVE 3 (SOS3); CONTAINS InterPro DOMAIN/s: Recoverin (InterPro:IPR001125), EF-HAND 2 (InterPro:IPR018249), Calcineurin B protein (InterPro:IPR015757), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: calcineurin B-like protein 8 (TAIR:AT1G64480.1).

NP_197815.1

SALT OVERLY SENSITIVE 3 (SOS3); CONTAINS InterPro DOMAIN/s: Recoverin (InterPro:IPR001125), EF-HAND 2 (InterPro:IPR018249), Calcineurin B protein (InterPro:IPR015757), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: calcineurin B-like protein 8 (TAIR:AT1G64480.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

8238428..8243443 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001343862.1 → NP_001331303.1 Calcium-binding EF-hand family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O81223

UniProtKB/TrEMBL

A0A178UAZ2, A0A384LPH6, A0A654G4H1, M5BEL7, M5BF43, M5BFD5

Conserved Domains (1) summary

COG5126
Location:29 → 187

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001343861.1 → NP_001331304.1 Calcium-binding EF-hand family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BDK7

Conserved Domains (1) summary

COG5126
Location:28 → 140

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001203448.2 → NP_001190377.1 Calcium-binding EF-hand family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190377.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O81223

UniProtKB/TrEMBL

A0A178UAZ2, A0A384LPH6, A0A654G4H1, M5BEL7, M5BF43, M5BFD5

Conserved Domains (1) summary

COG5126
Location:29 → 187

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_122333.6 → NP_197815.1 Calcium-binding EF-hand family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197815.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O81223

UniProtKB/TrEMBL

A0A178UAZ2, A0A384LPH6, A0A654G4H1, M5BEL7, M5BF43, M5BFD5

Conserved Domains (1) summary

COG5126
Location:29 → 187

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
NM_001343863.1 → NP_001331302.1 Calcium-binding EF-hand family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UCT8, A0A1P8BDI3, A0A384LGK3, M5BEL7

Conserved Domains (1) summary

COG5126
Location:7 → 162

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]