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    GLT1 NADH-dependent glutamate synthase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835427, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLT1
    Official Full Name
    NADH-dependent glutamate synthase 1
    Primary source
    TAIR:AT5G53460
    Locus tag
    AT5G53460
    See related
    Araport:AT5G53460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MYN8.7; MYN8_7; NADH-dependent glutamate synthase 1; NADH-GOGAT
    Summary
    NADH-dependent glutamate synthase
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    Genomic context

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    See GLT1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    20
    Sequence:
    Chromosome: 5; NC_003076.8 (21700187..21710296)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene OBP3-responsive protein 1 Neighboring gene ncRNA Neighboring gene acyl-CoA binding protein 1 Neighboring gene ARM repeat superfamily protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis glt1-T mutant defines a role for NADH-GOGAT in the non-photorespiratory ammonium assimilatory pathway. Lancien M, et al. Plant J, 2002 Feb. PMID 11844111
    2. Use of Arabidopsis mutants and genes to study amide amino acid biosynthesis. Lam HM, et al. Plant Cell, 1995 Jul. PMID 7640525, Free PMC Article
    3. The Arabidopsis GTL1 transcription factor regulates water use efficiency and drought tolerance by modulating stomatal density via transrepression of SDD1. Yoo CY, et al. Plant Cell, 2010 Dec. PMID 21169508, Free PMC Article
    4. Capturing the phosphorylation and protein interaction landscape of the plant TOR kinase. Van Leene J, et al. Nat Plants, 2019 Mar. PMID 30833711
    5. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203600.1
    NM_001203601.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutamate synthase (NADH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutamate synthase (NADH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-glutamate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ammonia assimilation cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glutamate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutamate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nitrate assimilation TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in plastid HDA PubMed 
    located_in plastid TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADH-dependent glutamate synthase 1
    NP_001190529.1
    • NADH-dependent glutamate synthase 1 (GLT1); CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Glutamine amidotransferase, class-II (InterPro:IPR000583), Aldolase-type TIM barrel (InterPro:IPR013785), Glutamate synthase, alpha subunit, C-terminal (InterPro:IPR002489), Adrenodoxin reductase (InterPro:IPR000759), Glutamate synthase, NADH/NADPH, small subunit 1 (InterPro:IPR006005), Fumarate reductase, C-terminal (InterPro:IPR012285), Glutamate synthase, central-N (InterPro:IPR006982), NAD(P)-binding domain (InterPro:IPR016040), Alpha-helical ferredoxin (InterPro:IPR009051), Glutamate synthase, eukaryotic (InterPro:IPR012220), Glutamate synthase, central-C (InterPro:IPR002932), Glutamine amidotransferase, type II (InterPro:IPR017932); BEST Arabidopsis thaliana protein match is: glutamate synthase 1 (TAIR:AT5G04140.1).
    NP_001190530.1
    • NADH-dependent glutamate synthase 1 (GLT1); CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Glutamine amidotransferase, class-II (InterPro:IPR000583), Aldolase-type TIM barrel (InterPro:IPR013785), Glutamate synthase, alpha subunit, C-terminal (InterPro:IPR002489), Glutamate synthase, NADH/NADPH, small subunit 1 (InterPro:IPR006005), Adrenodoxin reductase (InterPro:IPR000759), Fumarate reductase, C-terminal (InterPro:IPR012285), Glutamate synthase, central-N (InterPro:IPR006982), NAD(P)-binding domain (InterPro:IPR016040), Glutamate synthase, eukaryotic (InterPro:IPR012220), Alpha-helical ferredoxin (InterPro:IPR009051), Glutamate synthase, central-C (InterPro:IPR002932), Glutamine amidotransferase, type II (InterPro:IPR017932); BEST Arabidopsis thaliana protein match is: glutamate synthase 1 (TAIR:AT5G04140.1).
    NP_200158.2
    • NADH-dependent glutamate synthase 1 (GLT1); FUNCTIONS IN: glutamate synthase (NADH) activity; INVOLVED IN: nitrate assimilation, response to cadmium ion, glutamate biosynthetic process; LOCATED IN: chloroplast stroma, chloroplast, plastid; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Glutamine amidotransferase, class-II (InterPro:IPR000583), Glutamate synthase, alpha subunit, C-terminal (InterPro:IPR002489), Aldolase-type TIM barrel (InterPro:IPR013785), Adrenodoxin reductase (InterPro:IPR000759), Glutamate synthase, NADH/NADPH, small subunit 1 (InterPro:IPR006005), Fumarate reductase, C-terminal (InterPro:IPR012285), Glutamate synthase, central-N (InterPro:IPR006982), Glutamate synthase, eukaryotic (InterPro:IPR012220), NAD(P)-binding domain (InterPro:IPR016040), Alpha-helical ferredoxin (InterPro:IPR009051), Glutamate synthase, central-C (InterPro:IPR002932), Glutamine amidotransferase, type II (InterPro:IPR017932); BEST Arabidopsis thaliana protein match is: glutamate synthase 1 (TAIR:AT5G04140.1); Has 36461 Blast hits to 36289 proteins in 2576 species: Archae - 608; Bacteria - 18616; Metazoa - 663; Fungi - 406; Plants - 546; Viruses - 0; Other Eukaryotes - 15622 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21700187..21710296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124725.5 → NP_200158.2  NADH-dependent glutamate synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200158.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WL27, Q56W62, Q8LPH2, Q9LV03
      UniProtKB/TrEMBL
      A0A5S9YDS4, A0A654GAI8
      Conserved Domains (8) summary
      PRK11750
      Location:106 → 1627
      gltB; glutamate synthase subunit alpha; Provisional
      PRK12810
      Location:1704 → 2186
      gltD; glutamate synthase subunit beta; Reviewed
      cd00982
      Location:1378 → 1627
      gltB_C; gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the ...
      cd02808
      Location:951 → 1332
      GltS_FMN; Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast ...
      pfam00310
      Location:117 → 544
      GATase_2; Glutamine amidotransferases class-II
      pfam04898
      Location:594 → 882
      Glu_syn_central; Glutamate synthase central domain
      pfam13450
      Location:1850 → 1884
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl19102
      Location:1741 → 1834
      Fer4_8; 4Fe-4S dicluster domain

    2. NM_001203601.1 → NP_001190530.1  NADH-dependent glutamate synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190530.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WL27, Q56W62, Q8LPH2, Q9LV03
      UniProtKB/TrEMBL
      A0A5S9YDS4, A0A654GAI8
      Conserved Domains (8) summary
      PRK11750
      Location:106 → 1627
      gltB; glutamate synthase subunit alpha; Provisional
      PRK12810
      Location:1704 → 2186
      gltD; glutamate synthase subunit beta; Reviewed
      cd00982
      Location:1378 → 1627
      gltB_C; gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the ...
      cd02808
      Location:951 → 1332
      GltS_FMN; Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast ...
      pfam00310
      Location:117 → 544
      GATase_2; Glutamine amidotransferases class-II
      pfam04898
      Location:594 → 882
      Glu_syn_central; Glutamate synthase central domain
      pfam13450
      Location:1850 → 1884
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl19102
      Location:1741 → 1834
      Fer4_8; 4Fe-4S dicluster domain

    3. NM_001203600.1 → NP_001190529.1  NADH-dependent glutamate synthase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190529.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WL27, Q56W62, Q8LPH2, Q9LV03
      UniProtKB/TrEMBL
      A0A5S9YDS4, A0A654GAI8
      Conserved Domains (8) summary
      PRK11750
      Location:106 → 1627
      gltB; glutamate synthase subunit alpha; Provisional
      PRK12810
      Location:1704 → 2186
      gltD; glutamate synthase subunit beta; Reviewed
      cd00982
      Location:1378 → 1627
      gltB_C; gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the ...
      cd02808
      Location:951 → 1332
      GltS_FMN; Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast ...
      pfam00310
      Location:117 → 544
      GATase_2; Glutamine amidotransferases class-II
      pfam04898
      Location:594 → 882
      Glu_syn_central; Glutamate synthase central domain
      pfam13450
      Location:1850 → 1884
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      cl19102
      Location:1741 → 1834
      Fer4_8; 4Fe-4S dicluster domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LV03.2

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