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    DXR 1-deoxy-D-xylulose 5-phosphate reductoisomerase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836400, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DXR
    Official Full Name
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
    Primary source
    TAIR:AT5G62790
    Locus tag
    AT5G62790
    See related
    Araport:AT5G62790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    1-deoxy-D-xylulose 5-phosphate reductoisomerase; 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE; MQB2.90; MQB2_90; PDE129; PIGMENT-DEFECTIVE EMBRYO 129
    Summary
    1-Deoxy-d-xylulose 5-phosphate reductoisomerase (DXR) catalyzes the first committed step of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis. In Arabidopsis, DXR is encoded by a single-copy gene. Arabidopsis DXR is targeted to plastids and localizes into chloroplasts of leaf cells. DXR knockout or strongly silenced lines have a seedling lethal, albino phenotype. Transgenicly silenced lines expressing 35S:DXR have a variegated phenotype.
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    Genomic context

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    See DXR in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (25214125..25217469, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene membrane-associated kinase regulator, putative (DUF1645) Neighboring gene Chaperone DnaJ-domain superfamily protein Neighboring gene Protein with RING/U-box and TRAF-like domain Neighboring gene peroxin 14 Neighboring gene Uncharacterized protein family (UPF0497)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) gene results in albino, dwarf and defects in trichome initiation and stomata closure in Arabidopsis. Xing S, et al. Cell Res, 2010 Jun. PMID 20404857
    2. Enhanced flux through the methylerythritol 4-phosphate pathway in Arabidopsis plants overexpressing deoxyxylulose 5-phosphate reductoisomerase. Carretero-Paulet L, et al. Plant Mol Biol, 2006 Nov. PMID 16941216
    3. Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway. Carretero-Paulet L, et al. Plant Physiol, 2002 Aug. PMID 12177470, Free PMC Article
    4. Cloning and heterologous expression of a cDNA encoding 1-deoxy-D-xylulose-5-phosphate reductoisomerase of Arabidopsis thaliana. Schwender J, et al. FEBS Lett, 1999 Jul 16. PMID 10428488
    5. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A critical role for the 2-C-methyl-D-erythritol-4-phosphate biosynthetic pathway in controlling biosynthesis of isoprenoids.
      Title: Disruption of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) gene results in albino, dwarf and defects in trichome initiation and stomata closure in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203671.1
    NM_125674.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADPH binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within isoprenoid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 

    General protein information

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    Preferred Names
    1-deoxy-D-xylulose 5-phosphate reductoisomerase
    NP_001190600.1
    • 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR); CONTAINS InterPro DOMAIN/s: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal (InterPro:IPR013512), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (InterPro:IPR003821), 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal (InterPro:IPR013644).
    NP_201085.1
    • 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR); FUNCTIONS IN: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity; INVOLVED IN: response to cadmium ion, response to light stimulus, isoprenoid biosynthetic process, isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal (InterPro:IPR013512), 1-deoxy-D-xylulose 5-phosphate reductoisomerase (InterPro:IPR003821), 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal (InterPro:IPR013644); Has 6813 Blast hits to 6813 proteins in 2049 species: Archae - 0; Bacteria - 4206; Metazoa - 6; Fungi - 0; Plants - 109; Viruses - 0; Other Eukaryotes - 2492 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25214125..25217469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125674.3 → NP_201085.1  1-deoxy-D-xylulose 5-phosphate reductoisomerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201085.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M6U2, Q9XFS9
      UniProtKB/TrEMBL
      A0A654GDN7
      Conserved Domains (4) summary
      PLN02696
      Location:24 → 477
      PLN02696; 1-deoxy-D-xylulose-5-phosphate reductoisomerase
      pfam02670
      Location:83 → 211
      DXP_reductoisom; 1-deoxy-D-xylulose 5-phosphate reductoisomerase
      pfam08436
      Location:225 → 308
      DXP_redisom_C; 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
      pfam13288
      Location:341 → 459
      DXPR_C; DXP reductoisomerase C-terminal domain

    2. NM_001203671.1 → NP_001190600.1  1-deoxy-D-xylulose 5-phosphate reductoisomerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654GDN7, F4K7T6
      Conserved Domains (4) summary
      PLN02696
      Location:23 → 497
      PLN02696; 1-deoxy-D-xylulose-5-phosphate reductoisomerase
      pfam02670
      Location:82 → 231
      DXP_reductoisom; 1-deoxy-D-xylulose 5-phosphate reductoisomerase
      pfam08436
      Location:245 → 328
      DXP_redisom_C; 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
      pfam13288
      Location:361 → 479
      DXPR_C; DXP reductoisomerase C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XFS9.2

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