CDR1 Eukaryotic aspartyl protease family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: CDR1
Official Full Name: Eukaryotic aspartyl protease family protein
Primary source: TAIR:AT5G33340
Locus tag: AT5G33340
See related: Araport:AT5G33340
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CONSTITUTIVE DISEASE RESISTANCE 1; F19N2.60; F19N2_60
Summary: Encodes a protein with aspartic protease activity (also known as aspartate-type endopeptidase activity). Overexpression of the gene was shown to lead to salicylic acid (SA)-mediated disease resistance upon exposure to the pathogen Pseudomonas syringae. Moreover, overexpression of this gene led to the upregulation of two pathogenesis-related genes PR1 and PR2. This upregulation was no longer observed in transgenic lines expressing the bacterial NahG gene encoding a hydroxylase suppressing SA accumulation.
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Recombinant CDR1 was characterized.
Title: Characterization of recombinant CDR1, an Arabidopsis aspartic proteinase involved in disease resistance.

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Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables aspartic-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of hydrogen peroxide metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of hydrogen peroxide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of salicylic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISM Inferred from Sequence Model more info

NP_198319.1

CONSTITUTIVE DISEASE RESISTANCE 1 (CDR1); CONTAINS InterPro DOMAIN/s: Peptidase aspartic (InterPro:IPR021109), Peptidase aspartic, catalytic (InterPro:IPR009007), Peptidase A1 (InterPro:IPR001461), Peptidase aspartic, active site (InterPro:IPR001969); BEST Arabidopsis thaliana protein match is: Eukaryotic aspartyl protease family protein (TAIR:AT1G64830.1); Has 3792 Blast hits to 3768 proteins in 339 species: Archae - 0; Bacteria - 0; Metazoa - 807; Fungi - 843; Plants - 1930; Viruses - 0; Other Eukaryotes - 212 (source: NCBI BLink).

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The following sections contain reference sequences that belong to a specific genome build. Explain