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    HPL1 hydroperoxide lyase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827215, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HPL1
    Official Full Name
    hydroperoxide lyase 1
    Primary source
    TAIR:AT4G15440
    Locus tag
    AT4G15440
    See related
    Araport:AT4G15440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CYP74B2; DL3766W; FCAALL.125; hydroperoxide lyase 1; HYDROPEROXIDE LYASE 1
    Summary
    Encodes a hydroperoxide lyase. Also a member of the CYP74B cytochrome p450 family. In the ecotype Columbia (Col) the gene contains a 10-nucleotide deletion in its first exon that causes it to code for a truncated protein that results in a non-functional hydroperoxide lyase.
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    Genomic context

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    See HPL1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (8835368..8838676)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Ubiquitin fusion degradation UFD1 family protein Neighboring gene ERD (early-responsive to dehydration stress) family protein Neighboring gene Senescence/dehydration-associated protein-like protein Neighboring gene glycine-rich protein Neighboring gene Bax inhibitor-1 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The activity of HYDROPEROXIDE LYASE 1 regulates accumulation of galactolipids containing 12-oxo-phytodienoic acid in Arabidopsis. Nilsson AK, et al. J Exp Bot, 2016 Sep. PMID 27422994, Free PMC Article
    2. Variations in CYP74B2 (hydroperoxide lyase) gene expression differentially affect hexenal signaling in the Columbia and Landsberg erecta ecotypes of Arabidopsis. Duan H, et al. Plant Physiol, 2005 Nov. PMID 16258015, Free PMC Article
    3. Substrate channeling in oxylipin biosynthesis through a protein complex in the plastid envelope of Arabidopsis thaliana. Pollmann S, et al. J Exp Bot, 2019 Mar 11. PMID 30690555, Free PMC Article
    4. A downstream mediator in the growth repression limb of the jasmonate pathway. Yan Y, et al. Plant Cell, 2007 Aug. PMID 17675405, Free PMC Article
    5. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AOS and HPL are plastid envelope enzymes in Arabidopsis thaliana but accumulate at different locations. Biochemical experiments identified AOS as a constituent of complexes also containing lipoxygenase 2 (LOX2) and allene oxide cyclase (AOC), which catalyze consecutive steps in JA precursor biosynthesis, while excluding the concurrent HPL reaction.
      Title: Substrate channeling in oxylipin biosynthesis through a protein complex in the plastid envelope of Arabidopsis thaliana.
    2. regulates accumulation of galactolipids containing 12-oxo-phytodienoic acid
      Title: The activity of HYDROPEROXIDE LYASE 1 regulates accumulation of galactolipids containing 12-oxo-phytodienoic acid in Arabidopsis.
    3. In vitro HPL (Hydroperoxide lyase)activity analyses show undetectable HPL activity in the Col ecotype and reduced amounts of hexanal and no detectable trans-2-hexenal generated in the Col ecotype.
      Title: Variations in CYP74B2 (hydroperoxide lyase) gene expression differentially affect hexenal signaling in the Columbia and Landsberg erecta ecotypes of Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_117633.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast envelope HDA PubMed 

    General protein information

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    Preferred Names
    hydroperoxide lyase 1
    NP_193279.1
    • hydroperoxide lyase 1 (HPL1); FUNCTIONS IN: electron carrier activity, monooxygenase activity, iron ion binding, heme binding; INVOLVED IN: fatty acid metabolic process, response to wounding; LOCATED IN: chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group IV (InterPro:IPR002403); BEST Arabidopsis thaliana protein match is: allene oxide synthase (TAIR:AT5G42650.1); Has 6712 Blast hits to 6702 proteins in 615 species: Archae - 25; Bacteria - 392; Metazoa - 3265; Fungi - 548; Plants - 2246; Viruses - 0; Other Eukaryotes - 236 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      8835368..8838676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117633.3 → NP_193279.1  hydroperoxide lyase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193279.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LF83, Q8RXK9, Q9SUL4
      UniProtKB/TrEMBL
      A0A178V609
      Conserved Domains (1) summary
      cl12078
      Location:1 → 384
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B3LF83.1

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