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    pof3 F-box protein Pof3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539527, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pof3
    Official Full Name
    F-box protein Pof3
    Primary source
    PomBase:SPCC338.16
    Locus tag
    SPOM_SPCC338.16
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See pof3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1345278..1347275, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitotic cohesin complex non-SMC subunit Rad21 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase subunit Wbp1 Neighboring gene ncRNA Neighboring gene adenosine kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fission yeast Mcl1 interacts with SCF(Pof3) and is required for centromere formation. Mamnun YM, et al. Biochem Biophys Res Commun, 2006 Nov 10. PMID 16997270
    2. New insights into donor directionality of mating-type switching in Schizosaccharomyces pombe. Maki T, et al. PLoS Genet, 2018 May. PMID 29852001, Free PMC Article
    3. F-box proteins Pof3 and Pof1 regulate Wee1 degradation and mitotic entry in fission yeast. Qiu C, et al. J Cell Sci, 2018 Feb 2. PMID 29361524
    4. Hsk1- and SCF(Pof3)-dependent proteolysis of S. pombe Ams2 ensures histone homeostasis and centromere function. Takayama Y, et al. Dev Cell, 2010 Mar 16. PMID 20230746, Free PMC Article
    5. Sde2: a novel nuclear protein essential for telomeric silencing and genomic stability in Schizosaccharomyces pombe. Sugioka-Sugiyama R, et al. Biochem Biophys Res Commun, 2011 Mar 18. PMID 21333630

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. propose that Hsk1 plays a vital role during post S phase in genome stability via SCF(Pof3)-mediated degradation of Ams2, thereby maintaining centromere integrity
      Title: Hsk1- and SCF(Pof3)-dependent proteolysis of S. pombe Ams2 ensures histone homeostasis and centromere function.
    2. isolate Mcl1 as an interaction partner of the F-box protein Pof3, which is a component of the ubiquitin ligase complex SCF(Pof3)
      Title: Fission yeast Mcl1 interacts with SCF(Pof3) and is required for centromere formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in donor selection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of mitotic cell cycle DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    F-box protein Pof3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1345278..1347275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023141.3 → NP_588152.1  F-box protein Pof3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588152.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74991
      Conserved Domains (4) summary
      sd00034
      Location:454 → 478
      LRR_AMN1; leucine-rich repeat [structural motif]
      sd00006
      Location:40 → 70
      TPR; TPR repeat [structural motif]
      pfam12937
      Location:136 → 173
      F-box-like; F-box-like
      pfam13414
      Location:7 → 71
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version

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