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    mRpL39 mitochondrial ribosomal protein L39 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39627, updated on 27-Dec-2024

    Summary

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    Official Symbol
    mRpL39provided by FlyBase
    Official Full Name
    mitochondrial ribosomal protein L39provided by FlyBase
    Primary source
    FLYBASE:FBgn0036462
    Locus tag
    Dmel_CG17166
    See related
    AllianceGenome:FB:FBgn0036462
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17166; Dmel\CG17166; MRP-L5; mRpL5
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in several structures, including Malpighian tubule primordium; adult head; anterior endoderm; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human MRPL39 (mitochondrial ribosomal protein L39). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mRpL39 in Genome Data Viewer
    Location:
    71B1-71B1; 3-42 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14997981..14999666, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14991081..14992766, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene minidiscs Neighboring gene Zinc/iron regulated transporter-related protein 71B Neighboring gene Proteasome beta2 subunit Neighboring gene Reversion-inducing-cysteine-rich protein with kazal motifs Neighboring gene Synaptotagmin beta Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Ishizuka A, et al. Genes Dev, 2002 Oct 1. PMID 12368261, Free PMC Article
    2. Genome-Wide Analysis of Drosophila RBf2 Protein Highlights the Diversity of RB Family Targets and Possible Role in Regulation of Ribosome Biosynthesis. Wei Y, et al. G3 (Bethesda), 2015 May 20. PMID 25999584, Free PMC Article
    3. Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster. Casad ME, et al. Genetics, 2011 Nov. PMID 21890737, Free PMC Article
    4. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. Suzuki T, et al. J Biol Chem, 2001 Jun 15. PMID 11279069
    5. A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye. Jasper H, et al. Dev Cell, 2002 Oct. PMID 12408803

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial large ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial ribosomal protein L39
    Names
    CG17166-PA
    mRpL39-PA
    mitochondrial ribosomal protein L5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      14997981..14999666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079351.4 → NP_524075.2  mitochondrial ribosomal protein L39 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524075.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SYN5, Q9VUJ0
      UniProtKB/TrEMBL
      G2J631
      Related
      FBpp0075425
      Conserved Domains (1) summary
      cd01667
      Location:65 → 123
      TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUJ0.2 Q9VUJ0

    Gene LinkOut

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