PlexB Plexin B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PlexBprovided by FlyBase
Official Full Name: Plexin Bprovided by FlyBase
Primary source: FLYBASE:FBgn0025740
Locus tag: Dmel_CG17245
See related: AllianceGenome:FB:FBgn0025740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17245; Dmel\CG17245; plex; plex B; Plex B; plexB; PLEXB
Summary: Predicted to enable semaphorin receptor activity. Involved in neuron development. Located in dendrite. Is expressed in several structures, including adult head; adult protocerebral bridge 1 glomerulus-fan-shaped body-round body type a neurons; larval central nervous system; myoblast; and presumptive embryonic/larval central nervous system. Used to study developmental disorder of mental health and obesity. Orthologous to several human genes including PLXNB1 (plexin B1); PLXNB2 (plexin B2); and PLXNB3 (plexin B3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 101F1-101F1; 4-0 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (32478..43778, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (53104..64404, complement)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Secreted semaphorin 2b (Sema-2b) acts through its transmembrane receptor Plexin B (PlexB) to locally attract neural processes to specific fan-shaped body (FB) laminae. Aberrant Sema-2b/PlexB signaling leads to select disruptions in neural lamination, and these disruptions result in the formation of ectopic inhibitory connections between subsets of FB neurons.
Title: Semaphorin 2b Regulates Sleep-Circuit Formation in the Drosophila Central Brain.
extracellular PlexB cleavage serves as a regulatory mechanism of PlexB signaling. Thus, the divergent roles of PlexB motifs in distinct steps of neural development contribute to its functional versatility in neural circuit assembly.
Title: Functional divergence of Plexin B structural motifs in distinct steps of Drosophila olfactory circuit assembly.
PlexB plays a multifaceted role in instructing the assembly of the Drosophila olfactory circuit through temporally-regulated expression patterns and expression level-dependent effects.
Title: Stepwise wiring of the Drosophila olfactory map requires specific Plexin B levels.
semaphorin 2b is a target-derived signal that acts upon presynaptic plexin B receptors to mediate the retrograde, homeostatic control of presynaptic neurotransmitter release at the neuromuscular junction in Drosophila; Sema2b-PlexB signalling regulates presynaptic homeostatic plasticity through the cytoplasmic protein Mical and the oxoreductase-dependent control of presynaptic actin
Title: Retrograde semaphorin-plexin signalling drives homeostatic synaptic plasticity.
This study demonstrated that the evidence that PlexB mediates not only Sema-2a/2b-dependent guidance functions, but also Sema-2a/2b-independent target recognition in establishing the segmental nerve a motor axon pathway.
Title: Differential ligand regulation of PlexB signaling in motor neuron axon guidance in Drosophila.
PlexinA functions to suppress excessive axonal branches and synapses and PlexinB facilitates axonal growth.
Title: Opposing roles of PlexinA and PlexinB in axonal branch and varicosity formation.
In the absence of PlexB, chordotonal afferent connectivity within the CNS is severely disrupted, resulting in specific larval behavioral deficits.
Title: A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS.
PlexB is a receptor for the secreted semaphorin Sema-2a
Title: Drosophila Plexin B is a Sema-2a receptor required for axon guidance.
nervy regulates repulsive axon guidance by linking the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) to the Semaphorin 1a receptor Plexin A
Title: Nervy links protein kinase a to plexin-mediated semaphorin repulsion.
Semaphorin 2a secreted by oenocytes signals through plexin B and plexin A to guide sensory axons in the Drosophila embryo, with PlexB play the major signaling role.
Title: Semaphorin 2a secreted by oenocytes signals through plexin B and plexin A to guide sensory axons in the Drosophila embryo.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IDA Inferred from Direct Assay more info	PubMed
involved_in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite self-avoidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in motor neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in olfactory bulb axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in sensory neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: plexin B

Names: CG17245-PA; CG17245-PB; PlexB-PA; PlexB-PB; Plexin-B; PlexinB; plexin; plexin and met-hepatocyte growth factor receptor-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

32478..43778 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258471.2 → NP_001245400.1 plexin B, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245400.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O96682, Q9V4A7

UniProtKB/TrEMBL

H9XVL5

Conserved Domains (7) summary

cd11236
Location:86 → 534

Sema_plexin_like; The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases

smart00423
Location:683 → 730

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:977 → 1095

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:888 → 976

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1097 → 1211

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:535 → 586

PSI; Plexin repeat

pfam08337
Location:1452 → 2017

Plexin_cytopl; Plexin cytoplasmic RasGAP domain
NM_079877.4 → NP_524616.2 plexin B, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524616.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O96682, Q9V4A7

UniProtKB/TrEMBL

H9XVL5

Related

FBpp0088246

Conserved Domains (7) summary

cd11236
Location:86 → 534

Sema_plexin_like; The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases

smart00423
Location:683 → 730

PSI; domain found in Plexins, Semaphorins and Integrins

cd01179
Location:977 → 1095

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:888 → 976

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01181
Location:1097 → 1211

IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:535 → 586

PSI; Plexin repeat

pfam08337
Location:1452 → 2017

Plexin_cytopl; Plexin cytoplasmic RasGAP domain