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    GstE8 Glutathione S transferase E8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37113, updated on 17-Dec-2024

    Summary

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    Official Symbol
    GstE8provided by FlyBase
    Official Full Name
    Glutathione S transferase E8provided by FlyBase
    Primary source
    FLYBASE:FBgn0063492
    Locus tag
    Dmel_CG17533
    See related
    AllianceGenome:FB:FBgn0063492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM08326; CG17533; Dmel\CG17533; DmGSTE8; Gst3-2; GST3-2; gste8; GSTE8
    Summary
    Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be located in cytoplasm. Is expressed in wing disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GstE8 in Genome Data Viewer
    Location:
    55C7-55C8; 2-85 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18407834..18408955)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14295339..14296460)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glutathione S transferase E6 Neighboring gene Glutathione S transferase E7 Neighboring gene Glutathione S transferase E9 Neighboring gene immune deficiency Neighboring gene Dodeca-satellite-binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Behavioral and Transcriptional Response to Selection for Olfactory Behavior in Drosophila. Brown EB, et al. G3 (Bethesda), 2020 Apr 9. PMID 32024668, Free PMC Article
    2. Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site. Wongsantichon J, et al. Biosci Rep, 2015 Oct 20. PMID 26487708, Free PMC Article
    3. The genetic architecture of methotrexate toxicity is similar in Drosophila melanogaster and humans. Kislukhin G, et al. G3 (Bethesda), 2013 Aug 7. PMID 23733889, Free PMC Article
    4. Cloning, expression and biochemical characterization of one Epsilon-class (GST-3) and ten Delta-class (GST-1) glutathione S-transferases from Drosophila melanogaster, and identification of additional nine members of the Epsilon class. Sawicki R, et al. Biochem J, 2003 Mar 1. PMID 12443531, Free PMC Article
    5. Structural and Thermodynamic Insights into Dimerization Interfaces of Drosophila Glutathione Transferases. Schwartz M, et al. Biomolecules, 2024 Jun 26. PMID 39062472, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutathione S transferase E8
    Names
    CG17533-PA
    CG17533-PB
    Glutathione-S-transferase E8
    GstE8-PA
    GstE8-PB
    NP_001286571.1
    NP_611330.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18407834..18408955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299642.1 → NP_001286571.1  glutathione S transferase E8, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZB73, R9Z3V2
      Conserved Domains (3) summary
      cd03177
      Location:91 → 209
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:4 → 196
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03045
      Location:4 → 77
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...

    2. NM_137486.5 → NP_611330.2  glutathione S transferase E8, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611330.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZB73, R9Z3V2
      Related
      FBpp0085857
      Conserved Domains (3) summary
      cd03177
      Location:91 → 209
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:4 → 196
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03045
      Location:4 → 77
      GST_N_Delta_Epsilon; GST_N family, Class Delta and Epsilon subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZB73 A1ZB73
    Q8T0X2 Q8T0X2
    Q8T8R2 Q8T8R2

    Gene LinkOut

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