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    Ube2v2 ubiquitin-conjugating enzyme E2 variant 2 [ Mus musculus (house mouse) ]

    Gene ID: 70620, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ube2v2provided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2 variant 2provided by MGI
    Primary source
    MGI:MGI:1917870
    See related
    Ensembl:ENSMUSG00000022674 AllianceGenome:MGI:1917870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MMS2; 6820402M05; 1110021H13Rik; 4632410D19Rik; 5730524P06Rik
    Summary
    Acts upstream of or within error-free postreplication DNA repair. Predicted to be located in nucleoplasm. Predicted to be part of UBC13-MMS2 complex. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; and embryo. Orthologous to human UBE2V2 (ubiquitin conjugating enzyme E2 V2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 12.0), CNS E14 (RPKM 9.0) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ube2v2 in Genome Data Viewer
    Location:
    16 A1- A2; 16 10.09 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (15368850..15412382, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (15550986..15594518, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40205 Neighboring gene predicted gene 7085 Neighboring gene STARR-seq mESC enhancer starr_40206 Neighboring gene predicted gene, 41424 Neighboring gene STARR-seq mESC enhancer starr_40207 Neighboring gene STARR-seq mESC enhancer starr_40208 Neighboring gene STARR-seq mESC enhancer starr_40209 Neighboring gene STARR-seq mESC enhancer starr_40211 Neighboring gene predicted gene 7748 Neighboring gene minichromosome maintenance complex component 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Angiotensin II type 2 receptor deletion enhances vascular senescence by methyl methanesulfonate sensitive 2 inhibition. Min LJ, et al. Hypertension, 2008 May. PMID 18362223
    2. Recurrent carcinoma of the rectum, surgical treatment. JACKSON BR, et al. Calif Med, 1959 Sep. PMID 14406273, Free PMC Article
    3. Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis. Franko J, et al. Biochim Biophys Acta, 2001 May 28. PMID 11406273
    4. The tomato Fni3 lysine-63-specific ubiquitin-conjugating enzyme and suv ubiquitin E2 variant positively regulate plant immunity. Mural RV, et al. Plant Cell, 2013 Sep. PMID 24076975, Free PMC Article
    5. Roles of mouse UBC13 in DNA postreplication repair and Lys63-linked ubiquitination. Ashley C, et al. Gene, 2002 Feb 20. PMID 12039045

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102399

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA double-strand break processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within error-free postreplication DNA repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of UBC13-MMS2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin conjugating enzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 variant 2
    Names
    methyl methanesulfonate sensitive 2
    ubc-like protein MMS2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159351.1 → NP_001152823.1  ubiquitin-conjugating enzyme E2 variant 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BY025619, CJ049747, CT010522
      Consensus CDS
      CCDS49771.1
      UniProtKB/Swiss-Prot
      Q9D2M8
      Related
      ENSMUSP00000111442.2, ENSMUST00000115776.2
      Conserved Domains (1) summary
      cl00154
      Location:14 → 103
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    2. NM_023585.4 → NP_076074.2  ubiquitin-conjugating enzyme E2 variant 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK028472, BY025619, CT010522
      Consensus CDS
      CCDS37265.1
      UniProtKB/Swiss-Prot
      A6X924, Q8BGH6, Q8CE99, Q8K2V7, Q9CYD7, Q9D2M8, Q9ERI8
      UniProtKB/TrEMBL
      Q4VBX4
      Related
      ENSMUSP00000111443.4, ENSMUST00000115777.10
      Conserved Domains (1) summary
      smart00212
      Location:14 → 145
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      15368850..15412382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246011.2 → XP_011244313.1  ubiquitin-conjugating enzyme E2 variant 2 isoform X1

      UniProtKB/TrEMBL
      A6X925
      Related
      ENSMUSP00000093951.4, ENSMUST00000096234.4
      Conserved Domains (1) summary
      smart00212
      Location:2 → 105
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D2M8.4 GenPept UniProtKB/Swiss-Prot:Q9D2M8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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