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    Antxrl anthrax toxin receptor-like [ Mus musculus (house mouse) ]

    Gene ID: 239029, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Antxrlprovided by MGI
    Official Full Name
    anthrax toxin receptor-likeprovided by MGI
    Primary source
    MGI:MGI:1925726
    See related
    Ensembl:ENSMUSG00000047441 AllianceGenome:MGI:1925726
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933430J11; 1700112N15Rik
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. Is expressed in testis. Orthologous to human ANTXRL (ANTXR like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 55.0) See more
    Orthologs
    human all
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    Genomic context

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    See Antxrl in Genome Data Viewer
    Location:
    14 B; 14 20.8 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33774625..33798280)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34052668..34076323)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 488 Neighboring gene predicted gene, 30083 Neighboring gene STARR-seq mESC enhancer starr_36360 Neighboring gene predicted gene 5460 Neighboring gene RIKEN cDNA A630023A22 gene Neighboring gene STARR-seq mESC enhancer starr_36361 Neighboring gene annexin A8 Neighboring gene predicted gene, 24998

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release. Szot C, et al. J Clin Invest, 2018 Jul 2. PMID 29863500, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    anthrax toxin receptor-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172808.2 → NP_766396.2  anthrax toxin receptor-like precursor

      See identical proteins and their annotated locations for NP_766396.2

      Status: VALIDATED

      Source sequence(s)
      AC164099, AK077206
      Consensus CDS
      CCDS26931.1
      UniProtKB/Swiss-Prot
      E9QNF3, Q8BVM2
      UniProtKB/TrEMBL
      A0A2U7XVH6
      Related
      ENSMUSP00000052816.4, ENSMUST00000058725.5
      Conserved Domains (2) summary
      cd01474
      Location:71 → 255
      vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
      pfam05587
      Location:250 → 351
      Anth_Ig; Anthrax receptor extracellular domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      33774625..33798280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247790.1 → XP_030103650.1  anthrax toxin receptor-like isoform X2

      Conserved Domains (3) summary
      cd01474
      Location:61 → 245
      vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
      pfam01456
      Location:342 → 408
      Mucin; Mucin-like glycoprotein
      pfam05587
      Location:240 → 341
      Anth_Ig; Anthrax receptor extracellular domain

    2. XM_017316010.1 → XP_017171499.1  anthrax toxin receptor-like isoform X1

      Conserved Domains (3) summary
      cd01474
      Location:71 → 255
      vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
      pfam01456
      Location:352 → 418
      Mucin; Mucin-like glycoprotein
      pfam05587
      Location:250 → 351
      Anth_Ig; Anthrax receptor extracellular domain

    3. XM_017316009.2 → XP_017171498.1  anthrax toxin receptor-like isoform X1

      Conserved Domains (3) summary
      cd01474
      Location:71 → 255
      vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
      pfam01456
      Location:352 → 418
      Mucin; Mucin-like glycoprotein
      pfam05587
      Location:250 → 351
      Anth_Ig; Anthrax receptor extracellular domain

    4. XM_017316011.2 → XP_017171500.1  anthrax toxin receptor-like isoform X3

      Conserved Domains (3) summary
      PRK08581
      Location:301 → 356
      PRK08581; amidase domain-containing protein
      cd01474
      Location:14 → 198
      vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
      pfam05587
      Location:193 → 294
      Anth_Ig; Anthrax receptor extracellular domain

    5. XM_030247789.1 → XP_030103649.1  anthrax toxin receptor-like isoform X1

      Conserved Domains (3) summary
      cd01474
      Location:71 → 255
      vWA_ATR; ATR (Anthrax Toxin Receptor): Anthrax toxin is a key virulence factor for Bacillus anthracis, the causative agent of anthrax. ATR is the cellular receptor for the anthrax protective antigen and facilitates entry of the toxin into cells. The VWA domain in ...
      pfam01456
      Location:352 → 418
      Mucin; Mucin-like glycoprotein
      pfam05587
      Location:250 → 351
      Anth_Ig; Anthrax receptor extracellular domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVM2.2 GenPept UniProtKB/Swiss-Prot:Q8BVM2

    Gene LinkOut

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