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    MATR3 matrin 3 [ Homo sapiens (human) ]

    Gene ID: 9782, updated on 4-Jan-2025

    Summary

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    Official Symbol
    MATR3provided by HGNC
    Official Full Name
    matrin 3provided by HGNC
    Primary source
    HGNC:HGNC:6912
    See related
    Ensembl:ENSG00000015479 MIM:164015; AllianceGenome:HGNC:6912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MPD2; ALS21; VCPDM
    Summary
    This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013]
    Expression
    Ubiquitous expression in brain (RPKM 79.2), thyroid (RPKM 60.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MATR3 in Genome Data Viewer
    Location:
    5q31.2
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (139274101..139331677)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (139800176..139857743)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138609790..138667366)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene SIL1 nucleotide exchange factor Neighboring gene ribosomal protein L12 pseudogene 21 Neighboring gene MPRA-validated peak5496 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16405 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138559318-138560164 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:138567539-138568038 Neighboring gene RNA, U6 small nuclear 572, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16406 Neighboring gene uncharacterized LOC124901081 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16407 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138629501-138630204 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:138630205-138630907 Neighboring gene small nucleolar RNA, H/ACA box 74D Neighboring gene Sharpr-MPRA regulatory region 13556 Neighboring gene small nucleolar RNA, H/ACA box 74A Neighboring gene small nucleolar RNA host gene 4 Neighboring gene RNA, 5S ribosomal pseudogene 195 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:138657767-138658966 Neighboring gene RN7SK pseudogene 64 Neighboring gene poly(A) binding protein interacting protein 2 Neighboring gene solute carrier family 23 member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Needle electromyography findings in patients with MATR3 mutation - A prospective study. Hanisch F, et al. Clin Neurophysiol, 2016 Apr. PMID 26899464
    2. Whole-body muscle MRI of patients with MATR3-associated distal myopathy reveals a distinct pattern of muscular involvement and highlights the value of whole-body examination. Mensch A, et al. J Neurol, 2020 Aug. PMID 32361838, Free PMC Article
    3. Matrin3 binds directly to intronic pyrimidine-rich sequences and controls alternative splicing. Uemura Y, et al. Genes Cells, 2017 Sep. PMID 28695676
    4. Genetic analysis of matrin 3 gene in French amyotrophic lateral sclerosis patients and frontotemporal lobar degeneration with amyotrophic lateral sclerosis patients. Millecamps S, et al. Neurobiol Aging, 2014 Dec. PMID 25158920
    5. Matrin-3 plays an important role in cell cycle and apoptosis for survival in malignant melanoma. Kuriyama H, et al. J Dermatol Sci, 2020 Nov. PMID 32943284

    See all (366) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of Matrin-3 in physiology and its dysregulation in disease.
      Title: The role of Matrin-3 in physiology and its dysregulation in disease.
    2. MATR3 pathogenic variants differentially impair its cryptic splicing repression function.
      Title: MATR3 pathogenic variants differentially impair its cryptic splicing repression function.
    3. Matrin-3 acts as a potential biomarker and promotes hepatocellular carcinoma progression by interacting with cell cycle-regulating genes.
      Title: Matrin-3 acts as a potential biomarker and promotes hepatocellular carcinoma progression by interacting with cell cycle-regulating genes.
    4. Matrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions.
      Title: Matrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions.
    5. The effect on m[6]A methylation writer complex by the reduced MATR3 in pterygium.
      Title: The effect on m(6)A methylation writer complex by the reduced MATR3 in pterygium.
    6. MATR3 is an endogenous inhibitor of DUX4 in FSHD muscular dystrophy.
      Title: MATR3 is an endogenous inhibitor of DUX4 in FSHD muscular dystrophy.
    7. Neuronal activity regulates Matrin 3 abundance and function in a calcium-dependent manner through calpain-mediated cleavage and calmodulin binding.
      Title: Neuronal activity regulates Matrin 3 abundance and function in a calcium-dependent manner through calpain-mediated cleavage and calmodulin binding.
    8. LncRNA15691 promotes T-ALL infiltration by upregulating CCR9 via increased MATR3 stability.
      Title: LncRNA15691 promotes T-ALL infiltration by upregulating CCR9 via increased MATR3 stability.
    9. Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.
      Title: Matr3 reshapes m6A modification complex to alleviate macrophage inflammation during atherosclerosis.
    10. Prognostic significance of MATR3 in stage I and II non-small cell lung cancer patients.
      Title: Prognostic significance of MATR3 in stage I and II non-small cell lung cancer patients.
    Submit: New GeneRIF Correction See all GeneRIFs (63)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Amyotrophic lateral sclerosis type 21
    MedGen: C3807521 OMIM: 606070 GeneReviews: Amyotrophic Lateral Sclerosis Overview
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    siRNA knockdown of MATR3 improves the ZAP-induced degradation of HIV-1 transcripts; MATR3 enhances HIV-1 replication PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify matrin 3 (MATR3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify matrin 3 (MATR3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify matrin 3 (MATR3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify matrin 3 (MATR3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    gag Overexpression of Matrin 3 increases HIV-1 Gag expression; knockdown of Matrin 3 decreases HIV-1 Gag expression PubMed
    Rev rev Association of PSF with MATR3 is involved in nuclear retention of unspliced HIV-1 RNA and Rev activity PubMed
    rev The interaction of HIV-1 Rev and Matrin 3 specifically requires the presence of a Rev-dependent RRE-containing RNA. Two RNA recognition motifs (residues 586-612) in Matrin 3 are required for activity on Rev/RRE PubMed
    rev HIV-1 Rev interacting protein, matrin 3 (MATR3), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with MATR3 is increased by RRE PubMed
    Tat tat Matrin 3 protein (MATR3) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of matrin 3 (MATR3) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    vpr HIV-1 Vpr is identified to have a physical interaction with matrin 3 (MATR3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC9105, KIAA0723, DKFZp686K0542, DKFZp686K23100

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in blastocyst formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heart valve development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-transcriptional regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ventricular septum development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane HDA PubMed 
    located_in nuclear inner membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    matrin-3
    Names
    vocal cord and pharyngeal weakness with distal myopathy

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012846.1 RefSeqGene

      Range
      24638..62575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001194954.2 → NP_001181883.1  matrin-3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      AA233906, AB018266, AC011404, AK307872, BX537365
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11
      Conserved Domains (3) summary
      smart00451
      Location:798 → 833
      ZnF_U1; U1-like zinc finger
      cd12714
      Location:398 → 473
      RRM1_MATR3; RNA recognition motif 1 in vertebrate matrin-3
      cd12715
      Location:496 → 575
      RRM2_MATR3; RNA recognition motif 2 in vertebrate matrin-3

    2. NM_001194955.2 → NP_001181884.1  matrin-3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      AA233906, AB018266, AC011404, AK316420, BX537365
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11
      Related
      ENSP00000482895.1, ENST00000618441.5
      Conserved Domains (3) summary
      smart00451
      Location:798 → 833
      ZnF_U1; U1-like zinc finger
      cd12714
      Location:398 → 473
      RRM1_MATR3; RNA recognition motif 1 in vertebrate matrin-3
      cd12715
      Location:496 → 575
      RRM2_MATR3; RNA recognition motif 2 in vertebrate matrin-3

    3. NM_001194956.2 → NP_001181885.1  matrin-3 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AA233906, AC011404, AK316420, BX537365
      Consensus CDS
      CCDS54908.1
      UniProtKB/TrEMBL
      B4DRS1
      Related
      ENSP00000423587.1, ENST00000503811.5
      Conserved Domains (3) summary
      smart00451
      Location:510 → 545
      ZnF_U1; U1-like zinc finger
      cd12714
      Location:110 → 185
      RRM1_MATR3; RNA recognition motif 1 in vertebrate matrin-3
      cd12715
      Location:208 → 287
      RRM2_MATR3; RNA recognition motif 2 in vertebrate matrin-3

    4. NM_001282278.2 → NP_001269207.1  matrin-3 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an exon which contains a portion of the 5' UTR and 5' coding region including the start codon, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (c) with a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AA233906, AB018266, AC011404, AK293952, AK307872, BX537365
      UniProtKB/TrEMBL
      B3KM87, B4DF66, Q5CZA7
      Conserved Domains (3) summary
      smart00451
      Location:460 → 495
      ZnF_U1; U1-like zinc finger
      cd12714
      Location:60 → 135
      RRM1_MATR3; RNA recognition motif 1 in vertebrate matrin-3
      cd12715
      Location:158 → 237
      RRM2_MATR3; RNA recognition motif 2 in vertebrate matrin-3

    5. NM_001400441.1 → NP_001387370.1  matrin-3 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/TrEMBL
      A8MXP9, Q68D11

    6. NM_001400442.1 → NP_001387371.1  matrin-3 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/TrEMBL
      A8MXP9, Q68D11

    7. NM_001400443.1 → NP_001387372.1  matrin-3 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/TrEMBL
      A8MXP9, Q68D11

    8. NM_001400444.1 → NP_001387373.1  matrin-3 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/TrEMBL
      A8MXP9, Q68D11

    9. NM_001400445.1 → NP_001387374.1  matrin-3 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC011404
      Consensus CDS
      CCDS93789.1
      UniProtKB/TrEMBL
      A8MXP9, Q68D11

    10. NM_001400447.1 → NP_001387376.1  matrin-3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11

    11. NM_001400448.1 → NP_001387377.1  matrin-3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11

    12. NM_001400450.1 → NP_001387379.1  matrin-3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11

    13. NM_001400451.1 → NP_001387380.1  matrin-3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11

    14. NM_001400452.1 → NP_001387381.1  matrin-3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11

    15. NM_001400453.1 → NP_001387382.1  matrin-3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11

    16. NM_001400454.1 → NP_001387383.1  matrin-3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11

    17. NM_001400455.1 → NP_001387384.1  matrin-3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11

    18. NM_001400456.1 → NP_001387385.1  matrin-3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11

    19. NM_001400457.1 → NP_001387386.1  matrin-3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11

    20. NM_001400458.1 → NP_001387387.1  matrin-3 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11

    21. NM_001400459.1 → NP_001387388.1  matrin-3 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/TrEMBL
      B4DRS1

    22. NM_001400460.1 → NP_001387389.1  matrin-3 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/TrEMBL
      Q5CZA7

    23. NM_001400461.1 → NP_001387390.1  matrin-3 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/TrEMBL
      B4DRS1

    24. NM_001400462.1 → NP_001387391.1  matrin-3 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/TrEMBL
      B3KM87, B4DF66, Q5CZA7

    25. NM_001400463.1 → NP_001387392.1  matrin-3 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/TrEMBL
      B3KM87, B4DF66, Q5CZA7

    26. NM_001400464.1 → NP_001387393.1  matrin-3 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/TrEMBL
      B3KM87, B4DF66, Q5CZA7

    27. NM_001400465.1 → NP_001387394.1  matrin-3 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/TrEMBL
      B3KM87, B4DF66, Q5CZA7

    28. NM_001400466.1 → NP_001387395.1  matrin-3 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/TrEMBL
      B3KM87, B4DF66, Q5CZA7

    29. NM_001400467.1 → NP_001387396.1  matrin-3 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC011404
      UniProtKB/TrEMBL
      B3KM87, B4DF66, Q5CZA7
      Related
      ENSP00000426030.1, ENST00000502499.5

    30. NM_018834.6 → NP_061322.2  matrin-3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      AA233906, AC011404, AY007157, BX537365
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11
      Related
      ENSP00000378284.3, ENST00000394805.8
      Conserved Domains (3) summary
      smart00451
      Location:798 → 833
      ZnF_U1; U1-like zinc finger
      cd12714
      Location:398 → 473
      RRM1_MATR3; RNA recognition motif 1 in vertebrate matrin-3
      cd12715
      Location:496 → 575
      RRM2_MATR3; RNA recognition motif 2 in vertebrate matrin-3

    31. NM_199189.3 → NP_954659.1  matrin-3 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      AA233906, AB018266, AC011404, AK307872, BX537365
      UniProtKB/Swiss-Prot
      B7ZAV5, D3DQC3, P43243, Q9UHW0, Q9UQ27
      UniProtKB/TrEMBL
      A0A0R4J2E8, Q68D11
      Conserved Domains (3) summary
      smart00451
      Location:798 → 833
      ZnF_U1; U1-like zinc finger
      cd12714
      Location:398 → 473
      RRM1_MATR3; RNA recognition motif 1 in vertebrate matrin-3
      cd12715
      Location:496 → 575
      RRM2_MATR3; RNA recognition motif 2 in vertebrate matrin-3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      139274101..139331677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      139800176..139857743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43243.2 GenPept UniProtKB/Swiss-Prot:P43243

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