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    Rpn10 Regulatory particle non-ATPase 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40388, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Rpn10provided by FlyBase
    Official Full Name
    Regulatory particle non-ATPase 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0015283
    Locus tag
    Dmel_CG7619
    See related
    AllianceGenome:FB:FBgn0015283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    5SA; 7619; CG7619; Dmel\CG7619; DmS5a; dRpn10; mu-54; p54; pros54; Pros54; rpn10; Rpn10/p54; S5a; S5A
    Summary
    Enables ubiquitin conjugating enzyme binding activity and zinc ion binding activity. Involved in mitotic sister chromatid segregation and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Part of proteasome regulatory particle. Is expressed in adult head and organism. Orthologous to human PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rpn10 in Genome Data Viewer
    Location:
    78D5-78D5; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21537000..21538582)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21530100..21531682)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Makorin 1 Neighboring gene pickpocket 5 Neighboring gene Cytochrome c oxidase subunit 8 Neighboring gene Vacuolar H[+] ATPase M9.7 subunit b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and sequencing a non-ATPase subunit of the regulatory complex of the Drosophila 26S protease. Haracska L, et al. Eur J Biochem, 1995 Aug 1. PMID 7649173
    2. A gene-coexpression network for global discovery of conserved genetic modules. Stuart JM, et al. Science, 2003 Oct 10. PMID 12934013
    3. STABILON, a Novel Sequence Motif That Enhances the Expression and Accumulation of Intracellular and Secreted Proteins. Rethi-Nagy Z, et al. Int J Mol Sci, 2022 Jul 25. PMID 35897744, Free PMC Article
    4. Mapping the ubiquitin-binding domains in the p54 regulatory complex subunit of the Drosophila 26S protease. Haracska L, et al. FEBS Lett, 1997 Jul 28. PMID 9256246
    5. Tissue- and developmental stage-specific changes in the subcellular localization of the 26S proteasome in the ovary of Drosophila melanogaster. Adám G, et al. Gene Expr Patterns, 2004 May. PMID 15053983

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rpn10 is targeted for degradation by Ube3a.
      Title: Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10.
    2. Ubiquitylation of p54
      Title: Ubiquitylation of Drosophila p54/Rpn10/S5a regulates its interaction with the UBA-UBL polyubiquitin receptors.
    3. S5a/Rpn10/p54 deletion caused larval-pupal polyphasic lethality, multiple mitotic defects, the accumulation of higher multimers of ubiquitinated proteins and a huge accumulation of defective 26S proteasome particles.
      Title: Deletion of proteasomal subunit S5a/Rpn10/p54 causes lethality, multiple mitotic defects and overexpression of proteasomal genes in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyubiquitin modification-dependent protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin conjugating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulatory particle non-ATPase 10
    Names
    54 kda mu particle subunit of 26S protease
    CG7619-PA
    CG7619-PB
    Rpn10-PA
    Rpn10-PB
    proteasome 54kD subunit
    subunit S5a

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21537000..21538582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079480.3 → NP_524204.1  regulatory particle non-ATPase 10, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524204.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55035, Q86R87, Q9V473
      UniProtKB/TrEMBL
      M9PIG8
      Related
      FBpp0078024
      Conserved Domains (1) summary
      cd01452
      Location:1 → 187
      VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...

    2. NM_001275239.1 → NP_001262168.1  regulatory particle non-ATPase 10, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262168.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P55035, Q86R87, Q9V473
      UniProtKB/TrEMBL
      M9PIG8
      Conserved Domains (1) summary
      cd01452
      Location:1 → 187
      VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PIG8 M9PIG8
    P55035.2 P55035

    Gene LinkOut

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