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    Manf Mesencephalic astrocyte-derived neurotrophic factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41983, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Manfprovided by FlyBase
    Official Full Name
    Mesencephalic astrocyte-derived neurotrophic factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027095
    Locus tag
    Dmel_CG7013
    See related
    AllianceGenome:FB:FBgn0027095
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:ParkEST188; ARP-like; CG7013; DMANF; Dmel\CG7013; DmManf; DmMANF; manf; MANF
    Summary
    Involved in several processes, including dopamine metabolic process; dopaminergic synaptic transmission; and neuron cellular homeostasis. Located in endoplasmic reticulum and extracellular region. Is expressed in several structures, including adult head; epidermis; gland; glial cell; and gut section. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in Parkinsonism; breast cancer; carcinoma (multiple); and pancreatic cancer. Orthologous to several human genes including MANF (mesencephalic astrocyte derived neurotrophic factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Manf in Genome Data Viewer
    Location:
    89B13-89B13; 3-58 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16349404..16350801)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12175126..12176523)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Sulfated Neighboring gene Splicing factor 2 Neighboring gene poils au dos Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene jiangshi

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mesencephalic Astrocyte-Derived Neurotrophic Factor Regulates Morphology of Pigment-Dispersing Factor-Positive Clock Neurons and Circadian Neuronal Plasticity in Drosophila melanogaster. Krzeptowski W, et al. Front Physiol, 2021. PMID 34646147, Free PMC Article
    2. Glial expression of DmMANF is required for the regulation of activity, sleep and circadian rhythms in the visual system of Drosophila melanogaster. Walkowicz L, et al. Eur J Neurosci, 2021 Sep. PMID 33666288
    3. Analysis of the conserved neurotrophic factor MANF in the Drosophila adult brain. Stratoulias V, et al. Gene Expr Patterns, 2015 May-Jul. PMID 25917377
    4. Downregulation of DmMANF in Glial Cells Results in Neurodegeneration and Affects Sleep and Lifespan in Drosophila melanogaster. Walkowicz L, et al. Front Neurosci, 2017. PMID 29163014, Free PMC Article
    5. Novel CDNF/MANF family of neurotrophic factors. Lindholm P, et al. Dev Neurobiol, 2010 Apr. PMID 20186704

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study employed the Drosophila genetics to screen for potential interaction partners of Drosophila Manf (DmManf) in vivo; show that DmManf plays a role in the development of Drosophila wing.
      Title: In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway.
    2. These data suggest a role for Manf in the regulation of Drosophila unfolded protein response.
      Title: Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster.
    3. DmMANF expression in the adult brain is much wider than in the embryonic and larval stages. It is expressed in both glia and neurons including dopaminergic neurons.
      Title: Analysis of the conserved neurotrophic factor MANF in the Drosophila adult brain.
    4. study offers further insights into the functional conservation between invertebrate and mammalian MANF/CDNF proteins and reveals the importance of the C-terminal domain for MANF activity in vivo
      Title: Characterization of the structural and functional determinants of MANF/CDNF in Drosophila in vivo model.
    5. role of MANF in multicellular organism development
      Title: Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes.
    6. DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons.
      Title: Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dopaminergic neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mesencephalic astrocyte-derived neurotrophic factor
    Names
    ARP-like
    CG7013-PA
    Manf-PA
    mesencephalic astrocyte-derived neurotrophic factor ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16349404..16350801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058097.6 → NP_477445.1  mesencephalic astrocyte-derived neurotrophic factor [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477445.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VEW4, Q9XZ63
      Related
      FBpp0082735
      Conserved Domains (1) summary
      pfam10208
      Location:27 → 170
      Armet; Degradation arginine-rich protein for mis-folding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XZ63.2 Q9XZ63

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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