mask multiple ankyrin repeats single KH domain [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: maskprovided by FlyBase
Official Full Name: multiple ankyrin repeats single KH domainprovided by FlyBase
Primary source: FLYBASE:FBgn0043884
Locus tag: Dmel_CG33106
See related: AllianceGenome:FB:FBgn0043884
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18671; CG31138; CG33106; CG6268; cg6313; CG6313; Dmel\CG33106; EC3-6; Mask; MASK
Summary: Enables protein kinase binding activity. Involved in several processes, including cellular component assembly involved in morphogenesis; negative regulation of establishment of blood-brain barrier; and positive regulation of signal transduction. Located in M band; Z disc; and cytosol. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including adult brain cell body rind; adult head; anterior endoderm; embryonic/larval midgut primordium; and ganglia. Orthologous to human ANKHD1-EIF4EBP3 (ANKHD1-EIF4EBP3 readthrough); ANKHD1 (ankyrin repeat and KH domain containing 1); and ANKRD17 (ankyrin repeat domain 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 95F3-95F5; 3-84 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (24230562..24250248)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (20056284..20075970)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhancing mask activity in dopaminergic neurons extends lifespan in flies.
Title: Enhancing mask activity in dopaminergic neurons extends lifespan in flies.
Mask, the Drosophila ankyrin repeat and KH domain-containing protein, affects microtubule stability.
Title: Mask, the Drosophila ankyrin repeat and KH domain-containing protein, affects microtubule stability.
Mask, a component of the Hippo pathway, is required for Drosophila eye morphogenesis.
Title: Mask, a component of the Hippo pathway, is required for Drosophila eye morphogenesis.
The authors show that Mask acts to promote nuclear import of Yki, and that addition of an ectopic nuclear localisation sequence to Yki is sufficient to bypass the requirement for Mask in Yki-driven tissue growth.
Title: Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability.
MASK is a positive regulator of Domeless dimerisation and protein levels.
Title: A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability.
Mask modulates the global abundance of K48- and K63-ubiquitinated proteins by regulating autophagy-lysosome-mediated degradation, but not ubiquitin-proteasome system (UPS) function.
Title: Mask mitigates MAPT- and FUS-induced degeneration by enhancing autophagy through lysosomal acidification.
miR-285 directly targets the Yki cofactor Mask to suppress Yki activity and down-regulates the expression of its downstream target cyclin E, a key regulator of cell cycle.
Title: miR-285-Yki/Mask double-negative feedback loop mediates blood-brain barrier integrity in Drosophila.
Human Mask homolog ANKHD1 may serve as a potential therapeutic target for treating Parkinson disease caused by pink1/parkin mutations.
Title: Mask loss-of-function rescues mitochondrial impairment and muscle degeneration of Drosophila pink1 and parkin mutants.
forms a complex with Yki and its binding partner, Scalloped (Sd), on target-gene promoters and is essential for Yki to drive transcription of target genes and tissue growth
Title: Mask proteins are cofactors of Yorkie/YAP in the Hippo pathway.
Mask is a novel cofactor for Yki/YAP required for optimal Yki/YAP activity during development and oncogenesis.
Title: Mask is required for the activity of the Hippo pathway effector Yki/YAP.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in compound eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flight	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy of mitochondrion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of establishment of blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of sevenless signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wound healing, spreading of cells	IGI Inferred from Genetic Interaction more info	PubMed
involved_in wound healing, spreading of epidermal cells	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: multiple ankyrin repeats single KH domain

Names: CG33106-PA; CG33106-PB; CG33106-PC; CG33106-PD; CG33106-PE; CG33106-PF; mask-PA; mask-PB; mask-PC; mask-PD; mask-PE; mask-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

24230562..24250248

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001260351.1 → NP_001247280.1 multiple ankyrin repeats single KH domain, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247280.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K725, A0A0H4XWY3

Conserved Domains (7) summary

smart00248
Location:2321 → 2349

ANK; ankyrin repeats

cd00105
Location:3049 → 3110

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd00204
Location:633 → 751

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:635 → 724

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:995 → 1046

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:716 → 771

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:633 → 661

ANK; ANK repeat [structural motif]
NM_176556.2 → NP_788733.1 multiple ankyrin repeats single KH domain, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788733.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NP19, Q8SX96, Q8T0H2, Q8T8Q4, Q8WRQ7, Q9VCA8

UniProtKB/TrEMBL

A0A0H4XWY3

Related

FBpp0083947

Conserved Domains (5) summary

PHA03095
Location:604 → 859

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:621 → 649

ANK; ANK repeat [structural motif]

pfam12796
Location:623 → 713

Ank_2; Ankyrin repeats (3 copies)

cl00098
Location:3038 → 3107

KH-I; K homology (KH) RNA-binding domain, type I

cl39094
Location:2382 → 2701

Ank_2; Ankyrin repeats (3 copies)
NM_001275975.1 → NP_001262904.1 multiple ankyrin repeats single KH domain, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262904.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHR8, A0A0H4XWY3

Conserved Domains (7) summary

smart00248
Location:2311 → 2339

ANK; ankyrin repeats

cd00105
Location:3039 → 3100

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd00204
Location:621 → 739

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:623 → 712

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:983 → 1034

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:704 → 759

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:621 → 649

ANK; ANK repeat [structural motif]
NM_176557.2 → NP_788734.1 multiple ankyrin repeats single KH domain, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788734.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q6NP19, Q8SX96, Q8T0H2, Q8T8Q4, Q8WRQ7, Q9VCA8

UniProtKB/TrEMBL

A0A0H4XWY3

Related

FBpp0083948

Conserved Domains (5) summary

PHA03095
Location:604 → 859

PHA03095; ankyrin-like protein; Provisional

sd00045
Location:621 → 649

ANK; ANK repeat [structural motif]

pfam12796
Location:623 → 713

Ank_2; Ankyrin repeats (3 copies)

cl00098
Location:3038 → 3107

KH-I; K homology (KH) RNA-binding domain, type I

cl39094
Location:2382 → 2701

Ank_2; Ankyrin repeats (3 copies)
NM_001275974.1 → NP_001262903.1 multiple ankyrin repeats single KH domain, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262903.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHZ8, A0A0H4XWY3

Conserved Domains (7) summary

smart00248
Location:1947 → 1975

ANK; ankyrin repeats

cd00105
Location:2675 → 2736

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd00204
Location:256 → 374

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:258 → 347

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:618 → 669

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:339 → 394

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:256 → 284

ANK; ANK repeat [structural motif]
NM_001300571.1 → NP_001287500.1 multiple ankyrin repeats single KH domain, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287500.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LHK4, A0A0H4XWY3

Conserved Domains (7) summary

smart00248
Location:1934 → 1962

ANK; ankyrin repeats

cd00105
Location:2662 → 2723

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd00204
Location:243 → 361

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:245 → 334

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:605 → 656

Ank_4; Ankyrin repeats (many copies)

pfam13857
Location:326 → 381

Ank_5; Ankyrin repeats (many copies)

sd00045
Location:243 → 271

ANK; ANK repeat [structural motif]