AP-2sigma Adaptor Protein complex 2, sigma subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: AP-2sigmaprovided by FlyBase
Official Full Name: Adaptor Protein complex 2, sigma subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0043012
Locus tag: Dmel_CG6056
See related: AllianceGenome:FB:FBgn0043012
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AP-2 sigma; AP2; AP2-sigma; aps2; cg6056; CG6056; Dmel\CG6056; sigma2; sigma2-ada
Summary: Enables clathrin adaptor activity. Involved in endocytosis. Part of AP-2 adaptor complex. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval garland cell; garland cell primordium; and head mesoderm. Human ortholog(s) of this gene implicated in familial hypocalciuric hypercalcemia 3. Orthologous to human AP2S1 (adaptor related protein complex 2 subunit sigma 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21269209..21270075, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (17094931..17095797, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables clathrin adaptor activity	IEA Inferred from Electronic Annotation more info
enables clathrin adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in clathrin-dependent endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of AP-2 adaptor complex	IEA Inferred from Electronic Annotation more info
part_of AP-2 adaptor complex	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
part_of membrane coat	IEA Inferred from Electronic Annotation more info

Names: AP-2sigma-PA; CG6056-PA; angur; clathrin AP-2 complex; sigma2-adaptin

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