U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pi4KIIIalpha Phosphatidylinositol 4-kinase III alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31247, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pi4KIIIalphaprovided by FlyBase
    Official Full Name
    Phosphatidylinositol 4-kinase III alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267350
    Locus tag
    Dmel_CG10260
    See related
    AllianceGenome:FB:FBgn0267350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10260; Dmel\CG10260; EG:BACR7C10.2; l(1)17-59; l(1)3Ah; l(1)VA722; l(1)zw2; PI4K; PI4KIIIA; PI4KIIIalpha; PI4KIII[[alpha]]; PI4KinaseIIIalpha; stt4; Stt4; zw-2; ZW-2; zw2
    Summary
    Predicted to enable 1-phosphatidylinositol 4-kinase activity. Involved in several processes, including phosphatidylinositol phosphate biosynthetic process; positive regulation of smoothened signaling pathway; and regulation of synaptic assembly at neuromuscular junction. Predicted to be active in cytoplasm and plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 84. Orthologous to several human genes including PI4KA (phosphatidylinositol 4-kinase alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pi4KIIIalpha in Genome Data Viewer
    Location:
    3A8-3A8; 1-1 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2624804..2633672)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2518837..2527705)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Tetraspanin 3A Neighboring gene seipin Neighboring gene brivido-3 Neighboring gene shaggy Neighboring gene long non-coding RNA:CR45197 Neighboring gene Helix loop helix protein 3B

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene. Zheng C, et al. Epigenetics, 2024 Dec. PMID 38525798, Free PMC Article
    2. The Drosophila l(1)zw10 gene product, required for accurate mitotic chromosome segregation, is redistributed at anaphase onset. Williams BC, et al. J Cell Biol, 1992 Aug. PMID 1339459, Free PMC Article
    3. Downregulation of RBO-PI4KIIIα Facilitates Aβ(42) Secretion and Ameliorates Neural Deficits in Aβ(42)-Expressing Drosophila. Zhang X, et al. J Neurosci, 2017 May 10. PMID 28424219, Free PMC Article
    4. Hyccin/FAM126A deficiency reduces glial enrichment and axonal sheath, which are rescued by overexpression of a plasma membrane-targeting PI4KIIIα in Drosophila. Zhang Q, et al. Biochem Biophys Res Commun, 2022 Jan 22. PMID 34894559
    5. An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily. Bourouis M, et al. EMBO J, 1990 Sep. PMID 2118107, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A PI4KIIIalpha protein complex is required for cell viability during Drosophila wing development.
      Title: A PI4KIIIα protein complex is required for cell viability during Drosophila wing development.
    2. Here, the authors show that the sole type I phosphatidylinositol transfer protein, Vibrator, controls asymmetric division of Drosophilaneural stem cells (NSCs) by physically anchoring myosin II regulatory light chain, Sqh, to the NSC cortex.
      Title: Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II.
    3. This study suggests the RBO-PI4KIIIalpha complex as a novel therapeutic target, and PI4KIIIalpha inhibitors as new drug candidates.
      Title: Downregulation of RBO-PI4KIIIα Facilitates Aβ(42) Secretion and Ameliorates Neural Deficits in Aβ(42)-Expressing Drosophila.
    4. PI4KIIIalpha is a vital regulator of a functionally distinct pool of PtdIns4P that is essential for PtdIns(4,5)P2-dependent processes in Drosophila development.
      Title: PI4KIIIα is required for cortical integrity and cell polarity during Drosophila oogenesis.
    5. Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling.
      Title: Drosophila PI4KIIIalpha is required in follicle cells for oocyte polarization and Hippo signaling.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in basement membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived egg chamber formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    phosphatidylinositol 4-kinase III alpha
    Names
    CG10260-PC
    CG10260-PD
    PI4KIIIalpha
    Pi4KIIIalpha-PC
    Pi4KIIIalpha-PD
    lethal (1) 3Ah
    phosphatidylinositol 4-kinase IIIalpha
    zeste-white 2
    NP_001259191.1
    NP_570014.3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2624804..2633672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272262.2 → NP_001259191.1  phosphatidylinositol 4-kinase III alpha, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259191.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDM4, Q9U1K8
      Conserved Domains (2) summary
      cd00871
      Location:1600 → 1775
      PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
      cd05167
      Location:1836 → 2153
      PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha

    2. NM_130658.3 → NP_570014.3  phosphatidylinositol 4-kinase III alpha, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570014.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1K8, Q9W4X4
      Conserved Domains (2) summary
      cd00871
      Location:1580 → 1755
      PI4Ka; Phosphoinositide 4-kinase(PI4K), accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. PI4K phosphorylates hydroxylgroup at position 4 on the ...
      cd05167
      Location:1816 → 2133
      PI4Kc_III_alpha; Catalytic domain of Type III Phosphoinositide 4-kinase alpha
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDM4 M9PDM4
    Q8MYR7 Q8MYR7
    Q9U1K8 Q9U1K8
    Q9W4X4 Q9W4X4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous