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    Zw10 Zeste-white 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47874, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Zw10provided by FlyBase
    Official Full Name
    Zeste-white 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0004643
    Locus tag
    Dmel_CG9900
    See related
    AllianceGenome:FB:FBgn0004643
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    abe; CG9900; Dmel\CG9900; Dsl1; dZW10; EG:BACR7C10.3; l(1)3Af; l(1)6-99; l(1)zw10; mit(1)15; Mit(1)15; mit(l)15; zw-10; ZW-10; zw10; ZW10
    Summary
    Enables small GTPase binding activity. Involved in several processes, including cytokinetic process; mitotic spindle assembly checkpoint signaling; and nuclear division. Located in Golgi apparatus; kinetochore; and spindle. Part of RZZ complex. Is expressed in several structures, including adult head; antennal anlage; central brain anlage; gland; and male germline cell. Orthologous to human ZW10 (zw10 kinetochore protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Zw10 in Genome Data Viewer
    Location:
    3A6-3A7; 1-1 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2604197..2606824)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2498230..2500857)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene egghead Neighboring gene Kinesin-like protein at 3A Neighboring gene SET and MYND domain containing, class 3 Neighboring gene eukaryotic translation initiation factor 3 subunit g1 Neighboring gene Tetraspanin 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neocentromere activity of structurally acentric mini-chromosomes in Drosophila. Williams BC, et al. Nat Genet, 1998 Jan. PMID 9425896
    2. ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme? Vallee RB, et al. Cell Cycle, 2006 Nov 1. PMID 17102640, Free PMC Article
    3. PLK1 phosphorylation of ZW10 guides accurate chromosome segregation in mitosis. Bellah SF, et al. J Mol Cell Biol, 2024 Jul 29. PMID 38402459, Free PMC Article
    4. Sister-chromatid cohesion via MEI-S332 and kinetochore assembly are separable functions of the Drosophila centromere. Lopez JM, et al. Curr Biol, 2000 Aug 24. PMID 10985388
    5. The rate of poleward chromosome motion is attenuated in Drosophila zw10 and rod mutants. Savoian MS, et al. Nat Cell Biol, 2000 Dec. PMID 11146661

    See all (131) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PLK1 phosphorylation of ZW10 guides accurate chromosome segregation in mitosis.
      Title: PLK1 phosphorylation of ZW10 guides accurate chromosome segregation in mitosis.
    2. Mitosis length is influenced by the spindle assembly checkpoint (SAC), and authors found that CAL1 interacts with the SAC protein and RZZ complex component Zw10 and thus constitutes the anchor for the recruitment of RZZ.
      Title: The checkpoint protein Zw10 connects CAL1-dependent CENP-A centromeric loading and mitosis duration in Drosophila cells.
    3. Zwilch localizes to kinetochores and kinetochore microtubules in a manner identical to ZW10 and ROD.
      Title: Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.
    4. Rod/Zw10 contributes to checkpoint activation by promoting Mad2 recruitment and to checkpoint inactivation by recruiting dynein/dynactin that subsequently removes Mad2 from attached kinetochores.
      Title: Recruitment of Mad2 to the kinetochore requires the Rod/Zw10 complex.
    5. ZW10 has roles in mitotic checkpoint control, dynein targeting and membrane trafficking with dynein [review]
      Title: ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme?
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Golgi vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cleavage furrow ingression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in male meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane addition at site of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Dsl1/NZR complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RZZ complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RZZ complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RZZ complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in acroblast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Zeste-white 10
    Names
    CG9900-PB
    Zw10-PB
    abnormal-eye
    mitotic 15
    zeste white 10

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2604197..2606824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080162.4 → NP_524901.2  Zeste-white 10 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524901.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4X9
      Related
      FBpp0070425
      Conserved Domains (1) summary
      pfam06248
      Location:20 → 574
      Zw10; Centromere/kinetochore Zw10
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T9C2 Q8T9C2
    Q9W4X9.2 Q9W4X9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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